Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 1.00 |
| ▸ | MLNR | O43193 | 1/20 | 0.63 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.63 |
| ▸ | DRD2 | P14416 | 1/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.63 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.63 |
| ▸ | CNR1 | P21554 | 1/20 | 0.63 |
| ▸ | DRD1 | P21728 | 1/20 | 0.63 |
| ▸ | DRD4 | P21917 | 1/20 | 0.63 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27817823 | 0.99 | KCNH2 (0.98) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL9150576 | 0.90 | KCNH2 (0.82) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL8640342 | 0.90 | KCNH2 (0.81) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL6599893 | 0.85 | KCNH2 (0.74) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL8642973 | 0.84 | KCNH2 (0.73) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL8240493 | 0.84 | KCNH2 (0.73) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL6967113 | 0.83 | KCNH2 (0.71) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL17510363 | 0.82 | KCNH2 (0.73) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL7337112 | 0.80 | KCNH2 (0.70) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL8638064 | 0.80 | KCNH2 (0.70) | KCNH2MLNRCACNA1FNR1I2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1243001-C | Process for the manufacture of sertindole | LUNDBECK & CO AS H (DK) | 2006-02-22 | — | — | CN | claimed |
| EP-1260511-B1 | Process for the preparation of 5-chloro-1-(4-fluorophenyl)-3-(1,2,3,6-tetrahydropyridin-4-yl)indole and method of manufacturing sertindole | LUNDBECK & CO AS H (DK) | 2004-12-29 | — | — | EP | claimed |
| EP-0983264-B1 | METHOD OF MANUFACTURING SERTINDOLE | LUNDBECK & CO AS H (DK) | 2004-02-04 | — | — | EP | claimed |
| EP-1260511-A1 | Process for the preparation of 5-chloro-1-(4-fluorophenyl)-3-(1,2,3,6-tetrahydropyridin-4-yl)indole and method of manufacturing sertindole | H. Lundbeck A/S (DK) | 2002-11-27 | — | — | EP | claimed |
| US-6335463-B1 | Method of manufacturing sertindole | H. LUNDBECK A/S (DK) | 2002-01-01 | — | — | US | claimed |
| CN-1261363-A | Process for the manufacture of sertindole | LUNDBECK & CO AS H (DK) | 2000-07-26 | — | — | CN | claimed |
| CN-101899036-B | Method for preparing sertindole by using alkyl imidazole type ionic liquid as solvent | UNIV ZHENGZHOU | 2012-12-19 | — | — | CN | disclosed |
| US-8088918-B2 | Noncardiotoxic pharmaceutical compounds | WILLIAMSBURG HOLDINGS LLC (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088918-B2 | Noncardiotoxic pharmaceutical compounds | WILLIAMSBURG HOLDINGS LLC (US) | 2012-01-03 | — | — | US | disclosed |
| CN-101899036-A | Method for preparing sertindole by using alkyl imidazole type ionic liquid as solvent | UNIV ZHENGZHOU | 2010-12-01 | — | — | CN | disclosed |
| CN-101362749-A | Sertindole synthesis method | SHANGHAI INST PHARM INDUSTRY (CN) | 2009-02-11 | — | — | CN | disclosed |
| US-20070212412-A1 | STABLE SOLID FORMULATION OF SERTINDOLE | H. LUNDBECK A/S (DK) | 2007-09-13 | — | — | US | disclosed |
| US-20070212412-A1 | STABLE SOLID FORMULATION OF SERTINDOLE | H. LUNDBECK A/S (DK) | 2007-09-13 | — | — | US | disclosed |
| EP-0726898-A1 | PHENYLINDOLE COMPOUNDS | H. LUNDBECK A/S (DK) | 1996-08-21 | — | — | EP | disclosed |
| EP-0575429-B1 | TREATMENT OF COGNITIVE DISORDERS | LUNDBECK & CO AS H (DK) | 1995-12-06 | — | — | EP | disclosed |
| US-5462948-A | Treatment of addiction to drugs and substances of abuse | H. LUNDBECK A/S (DK) | 1995-10-31 | — | — | US | disclosed |
| US-5444073-A | Administering 1-aryl-3-(4-piperidyl)-indole derivatives | H. LUNDBECK A/S (DK) | 1995-08-22 | — | — | US | disclosed |
| US-5439922-A | Administering dopamine antagonists having reduced side effects | H. LUNDBECK A/S (DK) | 1995-08-08 | — | — | US | disclosed |
| WO-1995012591-A1 | PHENYLINDOLE COMPOUNDS | H. LUNDBECK A/S (DK) | 1995-05-11 | — | — | WO | disclosed |
| EP-0533824-B1 | PIPERIDYL-SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 1994-11-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070212412-A1 | STABLE SOLID FORMULATION OF SERTINDOLE | TPH2, TPH1, SLC6A4 | KCNH2 182/4885MLNR 1195/4885CACNA1F 2527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.