Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.71 |
| ▸ | HTR1B | P28222 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 7/20 | 0.48 |
| ▸ | HTR6 | P50406 | 4/20 | 0.47 |
| ▸ | GABRP | O00591 | 1/20 | 0.47 |
| ▸ | GABRD | O14764 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.47 |
| ▸ | GABRE | P78334 | 1/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640342 | 0.88 | KCNH2 (0.81) | KCNH2HTR1BHTR1ADRD4DRD3 | |
| SCHEMBL2739092 | 0.83 | KCNH2 (1.00) | KCNH2HTR1BHTR1ADRD4DRD3 | |
| SCHEMBL6599893 | 0.83 | KCNH2 (0.74) | KCNH2HTR1BHTR1ADRD4DRD3 | |
| SCHEMBL8642973 | 0.82 | KCNH2 (0.73) | KCNH2HTR1BHTR1ADRD4DRD3 | |
| Hydrochloric Acid SCHEMBL27817823 | 0.82 | KCNH2 (0.98) | KCNH2HTR1BHTR1ADRD4DRD3 | |
| SCHEMBL8640447 | 0.79 | HTR1A (0.78) | KCNH2HTR1BHTR1ADRD4DRD3 | |
| SCHEMBL6579238 | 0.78 | KCNH2 (0.66) | KCNH2HTR1BHTR1ADRD4DRD3 | |
| SCHEMBL6966415 | 0.77 | GPR119 (0.47) | KCNH2HTR1BHTR1ADRD4DRD3 | |
| SCHEMBL6581472 | 0.76 | KCNH2 (0.64) | KCNH2HTR1BHTR1ADRD4DRD3 | |
| SCHEMBL6579260 | 0.76 | KCNH2 (0.64) | KCNH2HTR1BHTR1ADRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602889-B1 | 5-heteroaryl substituted indoles | H. LUNDBECK A.S. (DK) | 2003-08-05 | — | — | US | disclosed |
| EP-1068198-B1 | 5-HETEROARYL SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 2003-05-28 | — | — | EP | disclosed |
| EP-1068198-A1 | 5-HETEROARYL SUBSTITUTED INDOLES | H.Lundbeck A/S (DK) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999046259-A1 | 5-HETEROARYL SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |
| EP-0575430-B1 | PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF ADDICTION TO DRUGS AND SUBSTANCES OF ABUSE | LUNDBECK & CO AS H (DK) | 1998-08-05 | — | — | EP | disclosed |
| EP-0575429-B1 | TREATMENT OF COGNITIVE DISORDERS | LUNDBECK & CO AS H (DK) | 1995-12-06 | — | — | EP | disclosed |
| US-5462948-A | Treatment of addiction to drugs and substances of abuse | H. LUNDBECK A/S (DK) | 1995-10-31 | — | — | US | disclosed |
| US-5444073-A | Administering 1-aryl-3-(4-piperidyl)-indole derivatives | H. LUNDBECK A/S (DK) | 1995-08-22 | — | — | US | disclosed |
| US-5439922-A | Administering dopamine antagonists having reduced side effects | H. LUNDBECK A/S (DK) | 1995-08-08 | — | — | US | disclosed |
| EP-0533824-B1 | PIPERIDYL-SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 1994-11-09 | — | — | EP | disclosed |