Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxribtimine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 4/20 | 0.53 |
| ▸ | TK2 | O00142 | 2/20 | 0.53 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1883689 | 0.84 | TK1 (0.55) | TK1 | |
| SCHEMBL1883691 | 0.84 | TK1 (0.55) | TK1 | |
| Doxribtimine SCHEMBL8023808 | 0.81 | TK1 (0.72) | TK1TK2 | |
| Doxribtimine SCHEMBL8905917 | 0.80 | TK1 (0.71) | TK1TK2 | |
| Doxribtimine SCHEMBL2722555 | 0.80 | TK1 (0.73) | TK1TK2 | |
| Doxribtimine SCHEMBL14596596 | 0.80 | TK1 (0.73) | TK1TK2 | |
| Doxribtimine SCHEMBL12296879 | 0.80 | TK1 (0.73) | TK1TK2 | |
| Doxribtimine SCHEMBL10382149 | 0.80 | TK1 (0.73) | TK1TK2 | |
| Doxribtimine SCHEMBL21078835 | 0.80 | TK1 (0.73) | TK1TK2 | |
| Doxribtimine SCHEMBL767986 | 0.80 | TK1 (0.73) | TK1TK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719271-A | HYBRIDS; GENETIC ENGINEERING | ISIS PHARMACEUTICALS, INC. (US) | 1998-02-17 | — | — | US | disclosed |