SCHEMBL8640462

SCHEMBL8640462

CC(=O)c1c(NC=O)n(C)c(=O)[nH]c1=O

nearest known ligand 0.35

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
MEN1 O00255 2/20 0.34
CYP2C9 P11712 2/20 0.33
MAPT P10636 1/20 0.33
GAA P10253 2/20 0.32
KDM4E B2RXH2 1/20 0.31
HTT P42858 1/20 0.31
XDH P47989 1/20 0.30
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30
TSHR P16473 1/20 0.30
CYP1A2 P05177 4/20 0.30
CYP2C19 P33261 3/20 0.30
CYP3A4 P08684 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8639784 0.70 KMT2A (0.52) KMT2ANPC1RAB9AMEN1CYP2C9
SCHEMBL6673604 0.65 EPHX2 (0.42) KMT2ANPC1RAB9AMEN1MAPT
SCHEMBL1393668 0.62 MAPT (0.38) KMT2AMEN1CYP2C9MAPTKDM4E
SCHEMBL14649412 0.60 ALDH1A1 (0.37) KMT2ANPC1RAB9AMEN1MAPT
SCHEMBL18119894 0.59 KDM4E (0.38) KMT2AMEN1MAPTGAAKDM4E
SCHEMBL9847038 0.58 ALDH1A1 (0.34) MAPTALDH1A1TSHRCYP2C19CYP3A4
SCHEMBL25101408 0.55 DAO (0.36) MAPTGAAALDH1A1TSHRCYP3A4
SCHEMBL20929164 0.55 SMN1; SMN2 (0.51) KMT2AMEN1MAPTGAAKDM4E
SCHEMBL2553972 0.54 EPHX2 (0.46) KMT2ANPC1RAB9AMEN1MAPT
SCHEMBL10809246 0.54 CYP1A2 (0.53) KMT2ANPC1RAB9AMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5830672-A MEASUREMENT WITH ANTIBODIES OF DIFFERENT METABOLITES OF CAFFEINE AFTER DRINKING COFFEE MCGILL UNIVERSITY (CA) 1998-11-03 US claimed