Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1346046 | 0.80 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9AHPGDKMT2A | |
| SCHEMBL224315 | 0.80 | NPC1 (0.83) | SMN1; SMN2NPC1RAB9AHPGDKMT2A | |
| SCHEMBL11365372 | 0.80 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9AHPGDKMT2A | |
| SCHEMBL224762 | 0.80 | NPC1 (0.88) | SMN1; SMN2NPC1RAB9AHPGDKMT2A | |
| SCHEMBL1347033 | 0.79 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9AHPGDKMT2A | |
| SCHEMBL4779632 | 0.79 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9AHPGDKMT2A | |
| SCHEMBL19424137 | 0.78 | ALDH1A1 (0.61) | SMN1; SMN2NPC1RAB9AHPGDKMT2A | |
| SCHEMBL16324583 | 0.77 | HTT (0.67) | SMN1; SMN2NPC1RAB9AHPGDKMT2A | |
| SCHEMBL2328514 | 0.77 | NPC1 (0.48) | SMN1; SMN2NPC1RAB9AHPGDKMT2A | |
| SCHEMBL4731182 | 0.76 | NPC1 (0.86) | SMN1; SMN2NPC1RAB9AHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516257-B1 | Phenylbenzo[b]furans and -thiophenes, procedures for their preparation, and pharmaceutical compositions containing the same | SCHERING AG (DE) | 1998-08-05 | — | — | EP | disclosed |
| US-5470854-A | Antiestrogens | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-11-28 | — | — | US | disclosed |
| WO-1992021669-A1 | 2-PHENYLBENZO[B]FURANS AND THIOPHENES, METHODS OF PREPARING THEM AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-12-10 | — | — | WO | disclosed |
| EP-0516257-A1 | Phenylbenzo[b]furans and -thiophenes, procedures for their preparation, and pharmaceutical compositions containing the same | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-12-02 | — | — | EP | disclosed |