Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11175864 | 0.87 | ALDH1A1 (0.62) | ALDH1A1HPGDCYP3A4MAPK1RAB9A | |
| SCHEMBL8470680 | 0.79 | HPGD (0.53) | ALDH1A1HPGDCYP3A4MAPK1RAB9A | |
| SCHEMBL11761193 | 0.79 | ALDH1A1 (0.66) | ALDH1A1HPGDCYP3A4MAPK1RAB9A | |
| SCHEMBL13094612 | 0.79 | ALDH1A1 (0.71) | ALDH1A1HPGDCYP3A4MAPK1RAB9A | |
| SCHEMBL7080954 | 0.78 | ALDH1A1 (0.51) | ALDH1A1HPGDCYP3A4MAPK1RAB9A | |
| SCHEMBL8640585 | 0.78 | SMN1; SMN2 (0.59) | ALDH1A1HPGDCYP3A4RAB9ANPC1 | |
| SCHEMBL2975263 | 0.78 | KMT2A (0.47) | ALDH1A1HPGDCYP3A4MAPK1RAB9A | |
| SCHEMBL7681445 | 0.77 | KMT2A (0.59) | ALDH1A1HPGDCYP3A4MAPK1RAB9A | |
| SCHEMBL8636977 | 0.76 | TUBB1 (0.49) | ALDH1A1HPGDCYP3A4MAPK1KMT2A | |
| SCHEMBL8636973 | 0.76 | TUBB1 (0.49) | ALDH1A1HPGDCYP3A4MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795563-B1 | INDOLINE ANALOGS AND USES THEREOF | ONCTERNAL THERAPEUTICS INC (US) | 2024-07-17 | — | — | EP | disclosed |
| EP-3795563-A1 | INDOLINE ANALOGS AND USES THEREOF | Oncternal Therapeutics, Inc. (US) | 2021-03-24 | — | — | EP | disclosed |
| EP-3436434-B1 | INDOLINE ANALOGS AND USES THEREOF | ONCTERNAL THERAPEUTICS INC (US) | 2020-07-08 | — | — | EP | disclosed |
| US-10351569-B2 | Indoline analogs and uses thereof | Oncternal Therapeutics, Inc. (US) | 2019-07-16 | — | — | US | disclosed |
| US-20170349600-A1 | INDOLINE ANALOGS AND USES THEREOF | GEORGETOWN UNIVERSITY | 2017-12-07 | — | — | US | disclosed |
| US-9822122-B2 | Indoline analogs and uses thereof | Oncternal Therapeutics, Inc. (US) | 2017-11-21 | — | — | US | disclosed |
| WO-2017172368-A1 | INDOLINE ANALOGS AND USES THEREOF | Oncternal Therapeutics, Inc. (US) | 2017-10-05 | — | — | WO | disclosed |
| US-20170283420-A1 | INDOLINE ANALOGS AND USES THEREOF | GEORGETOWN UNIVERSITY | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10351569-B2 | Indoline analogs and uses thereof | FLI1, EWSR1, IKZF1 | ALDH1A1 2456/4885HPGD 3906/4885CYP3A4 4054/4885 |
| US-20170283420-A1 | INDOLINE ANALOGS AND USES THEREOF | FLI1, EWSR1, IKZF1 | ALDH1A1 2456/4885HPGD 3906/4885CYP3A4 4054/4885 |
| US-20170349600-A1 | INDOLINE ANALOGS AND USES THEREOF | FLI1, EWSR1, IKZF1 | ALDH1A1 2456/4885HPGD 3906/4885CYP3A4 4054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.