Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.58 |
| ▸ | HTR2C | P28335 | 3/20 | 0.58 |
| ▸ | HTR7 | P34969 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433902 | 0.83 | HTR2A (0.47) | HTR2AHTR2CHTR7SLC6A4SLC6A3 | |
| SCHEMBL8645119 | 0.83 | HTR2A (0.47) | HTR2AHTR2CHTR7SLC6A4SLC6A3 | |
| SCHEMBL8642030 | 0.81 | HTR2A (0.45) | HTR2AHTR2CHTR7CYP2D6HTR6 | |
| SCHEMBL9330147 | 0.81 | HTR2A (0.87) | HTR2AHTR2CHTR7KDM4ECYP1A2 | |
| SCHEMBL7444174 | 0.77 | HTR2A (0.59) | HTR2AHTR2CHTR7KDM4ECYP1A2 | |
| SCHEMBL7444179 | 0.77 | HTR2A (0.59) | HTR2AHTR2CHTR7KDM4ECYP1A2 | |
| SCHEMBL7444169 | 0.77 | HTR2A (0.59) | HTR2AHTR2CHTR7KDM4ECYP1A2 | |
| SCHEMBL9328582 | 0.76 | HTR2A (0.87) | HTR2AHTR2CHTR7KDM4ECYP1A2 | |
| SCHEMBL8643172 | 0.73 | SIGMAR1 (0.47) | — | |
| SCHEMBL9375973 | 0.73 | HTR2A (1.00) | HTR2AHTR2CHTR7KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731307-A | Neuroleptic 2,7-disubtituted perhydro-1h-pyrido 1, 2-A!pyrazines | PFIZER, INC. (US) | 1998-03-24 | — | — | US | claimed |