SCHEMBL8644576

SCHEMBL8644576

Clc1nnnc(Nc2ccccc2/C=C/c2ccccc2)c1Cl

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
NFE2L2 Q16236 3/20 0.36
TRPA1 O75762 2/20 0.36
NR1H2 P55055 1/20 0.35
SIGMAR1 Q99720 4/20 0.34
SNCA P37840 5/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
GRIN2D O15399 2/20 0.33
GRIN3B O60391 2/20 0.33
GRIN1 Q05586 2/20 0.33
GRIN2A Q12879 2/20 0.33
GRIN2B Q13224 2/20 0.33
GRIN2C Q14957 2/20 0.33
GRIN3A Q8TCU5 2/20 0.33
ATP4A P20648 2/20 0.33
ATP4B P51164 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8644581 1.00 MEN1 (0.38) MEN1KMT2ANFE2L2TRPA1NR1H2
SCHEMBL28705750 0.76 KDM4E (0.41) NFE2L2TRPA1NPC1RAB9AATP4A
SCHEMBL8431389 0.76 TSHR (0.44) KMT2ANPC1RAB9A
SCHEMBL2492770 0.75 NFE2L2 (0.54) NFE2L2TRPA1SIGMAR1SNCAGRIN2D
SCHEMBL2498783 0.70 SIRT2 (0.50) MEN1KMT2ANFE2L2TRPA1SIGMAR1
SCHEMBL2494333 0.69 SIRT2 (0.57) MEN1KMT2ANFE2L2TRPA1SIGMAR1
SCHEMBL285342 0.69 TRPA1 (0.38) MEN1KMT2ANFE2L2TRPA1SIGMAR1
SCHEMBL285344 0.69 TRPA1 (0.38) MEN1KMT2ANFE2L2TRPA1SIGMAR1
SCHEMBL29740231 0.66 SIGMAR1 (0.54) NFE2L2TRPA1SIGMAR1SNCARAB9A
SCHEMBL8340070 0.66 PLAU (0.46) MEN1KMT2ANFE2L2TRPA1SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0662634-B1 Ballasted optical brighteners EASTMAN KODAK CO (US) 1998-08-19 EP disclosed
EP-0662634-A1 Ballasted optical brighteners EASTMAN KODAK COMPANY (US) 1995-07-12 EP disclosed
US-5395748-A Triazino-type compound bonded directly to gelatin residue; storage stability crosslink-free EASTMAN KODAK COMPANY (US) 1995-03-07 US disclosed