Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.71 |
| ▸ | PLA2G2A | P14555 | 16/20 | 0.69 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | RGS12 | O14924 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017573 | 0.94 | PLA2G2A (0.74) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL8649352 | 0.84 | PLA2G2A (0.70) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL1320560 | 0.83 | LMNA (1.00) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL7963016 | 0.82 | PLA2G2A (1.00) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL8360250 | 0.78 | PLA2G2A (0.47) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL8358802 | 0.77 | PLA2G2A (0.47) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL8645716 | 0.77 | PLA2G2A (0.59) | PLA2G2APLA2G1B | |
| SCHEMBL27473629 | 0.76 | PLA2G2A (0.54) | PLA2G2APLA2G1BPTGS2 | |
| SCHEMBL14446495 | 0.76 | LMNA (0.89) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL7963230 | 0.76 | PLA2G2A (0.86) | LMNACYP1A2CYP3A4CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0746544-B1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMA INC (US) | 1998-09-09 | — | — | EP | disclosed |