SCHEMBL8645

SCHEMBL8645

O=C(O)Cc1ccccc1F

nearest known ligand 0.65

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CXCL8 P10145 2/20 0.65
AKR1B1 P15121 2/20 0.61
TDP1 Q9NUW8 1/20 0.53
ALDH1A1 P00352 4/20 0.53
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53
LMNA P02545 1/20 0.51
RAB9A P51151 1/20 0.51
PTGS2 P35354 2/20 0.50
MAPK1 P28482 1/20 0.50
KDM4E B2RXH2 1/20 0.47
PTGS1 P23219 1/20 0.47
BCAT2 O15382 1/20 0.47
TAAR1 Q96RJ0 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29533621 1.00 CXCL8 (0.65) CXCL8AKR1B1TDP1ALDH1A1MEN1
Fluoride SCHEMBL11183201 0.98 CXCL8 (0.62) CXCL8AKR1B1TDP1ALDH1A1MEN1
Ammonia Solution, Strong SCHEMBL4479018 0.98 CXCL8 (0.62) CXCL8AKR1B1TDP1ALDH1A1MEN1
Hydrochloric Acid SCHEMBL1371542 0.98 CXCL8 (0.62) CXCL8AKR1B1TDP1ALDH1A1MEN1
SCHEMBL6969660 0.84 ALDH1A1 (0.51) CXCL8ALDH1A1MEN1KMT2ALMNA
SCHEMBL4661911 0.84 ALDH1A1 (0.51) CXCL8ALDH1A1MEN1KMT2ALMNA
SCHEMBL8209127 0.84 CXCL8 (0.53) CXCL8AKR1B1ALDH1A1MEN1KMT2A
SCHEMBL538984 0.84 CXCL8 (0.57) CXCL8AKR1B1TDP1ALDH1A1MEN1
SCHEMBL27856925 0.83 CXCL8 (0.53) CXCL8AKR1B1TDP1ALDH1A1MEN1
SCHEMBL29410826 0.83 AKR1B1 (0.76) CXCL8AKR1B1TDP1LMNAPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2138 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 EP claimed
CN-119414657-A Fluorine-containing titanium oxide nanoparticle photoresist material, preparation method thereof and application thereof in photoetching technology 山东大学 2025-02-11 CN claimed
US-20250034297-A1 VANADIUM-BASED CATALYTIC SYSTEM INCLUDING ACTIVATOR AND METHOD FOR OLEFIN POLYMERIZATION CHANGCHUN UNIVERSITY OF TECHNOLOGY (CN) 2025-01-30 US claimed
WO-2024167565-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS PURDUE RESEARCH FOUNDATION (US) 2024-08-15 WO claimed
CN-118184679-A Photothermal agent and preparation method thereof, photothermal nanoparticle and preparation method thereof, insulating material and self-repairing method of insulating material 中国石油天然气股份有限公司 2024-06-14 CN claimed
CN-117143097-A Beta-carbopol compound, preparation method thereof and application of beta-carbopol compound in resisting Alzheimer disease 中国人民解放军北部战区总医院 2023-12-01 CN claimed
US-20230312474-A1 PHENOL DERIVATIVE Sumitomo Pharma Co., Ltd. (JP) 2023-10-05 US claimed
CN-116836081-A Ether epoxy toughening agent and preparation method and application thereof 中国林业科学研究院林产化学工业研究所 2023-10-03 CN claimed
EP-4206184-A1 PHENOL DERIVATIVE Sumitomo Pharma Co., Ltd. (JP) 2023-07-05 EP claimed
CN-115939514-A Hydrolysis-resistant functional additive, preparation method thereof and application thereof in solid electrolyte 华南理工大学 2023-04-07 CN claimed
US-6946025-B2 Process for preparing tetra-amide compounds XEROX CORPORATION (US) 2005-09-20 US claimed
EP-1373240-B1 RETINOID X RECEPTOR MODULATORS LILLY CO ELI (US) 2005-06-15 EP claimed
US-20050090690-A1 Process for preparing tetra-amide compounds XEROX CORPORATION 2005-04-28 US claimed
US-20040167160-A1 Retinoid x receptor modulators LIGAND PHARMACEUTICALS INCORPORATED 2004-08-26 US claimed
EP-1373240-A2 RETINOID X RECEPTOR MODULATORS ELI LILLY AND COMPANY (US) 2004-01-02 EP claimed
WO-2002071827-A2 RETINOID X RECEPTOR MODULATORS ELI LILLY AND COMPANY (US) 2002-09-19 WO claimed
US-6403646-B1 ADMINISTERING PHENYLBUTYRIC ACID OR DERIVATIVES TO TREAT LIVER DISEASE AND EMPHYSEMA CAUSED BY PROTEASE INHIBITOR TYPE Z MUTATION; STIMULATES SECRETION WITHOUT INCREASING SYNTHESIS OF PROTEIN PERLMUTTER DAVID H (US) 2002-06-11 US claimed
US-4740510-A Derivatives of alpha-(2-oxo 2,4,5,6,7,7a-hexahydro thieno[3,2-c]5-pyridyl) phenyl acetic acid, and their use as platelet and thrombotic aggregation inhibitors SANOFI (S.A.) (FR) 1988-04-26 US claimed
EP-0099802-B1 THIENO(3,2-C) PYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL USE ELF SANOFI (FR) 1987-02-04 EP claimed
US-4411974-A FOR NEGATIVE TONERS XEROX CORPORATION (US) 1983-10-25 US claimed