Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 4/20 | 0.44 |
| ▸ | IL1RN | P18510 | 2/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641893 | 0.96 | HSD17B10 (0.45) | HSD17B10ERAP2ERAP1IL1RNMMP8 | |
| SCHEMBL8642481 | 0.90 | ERAP2 (0.46) | HSD17B10ERAP2ERAP1IL1RNMMP8 | |
| SCHEMBL8636698 | 0.87 | ERAP2 (0.45) | ERAP2ERAP1IL1RNMMP8LNPEP | |
| SCHEMBL8641877 | 0.82 | GPR88 (0.36) | HSD17B10ERAP2ERAP1IL1RNMMP8 | |
| SCHEMBL8641846 | 0.80 | MMP3 (0.36) | HSD17B10ERAP2ERAP1IL1RNLNPEP | |
| SCHEMBL7600979 | 0.73 | HSD17B10 (0.64) | HSD17B10MMP3 | |
| SCHEMBL7507978 | 0.72 | HSD17B10 (0.52) | HSD17B10 | |
| SCHEMBL1858600 | 0.72 | GRIK1 (0.54) | MMP2MMP3 | |
| SCHEMBL9698601 | 0.71 | HSD17B10 (0.56) | HSD17B10MMP3 | |
| SCHEMBL6924893 | 0.70 | HSD17B10 (0.58) | HSD17B10MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0766687-B1 | PHOSPHINIC ACID DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 1998-08-05 | — | — | EP | disclosed |
| US-5739123-A | ANGIOTENSIN CONVERTING ENZYME INHIBITOR TREATING CARDIOVASCULAR DISEASES | ZAMBON GROUP S.P.A. (IT) | 1998-04-14 | — | — | US | disclosed |
| EP-0766687-A1 | PHOSPHINIC ACID DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON GROUP S.p.A. (IT) | 1997-04-09 | — | — | EP | disclosed |
| WO-1995035302-A1 | PHOSPHINIC ACID DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 1995-12-28 | — | — | WO | disclosed |