Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.45 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.45 |
| ▸ | IL1RN | P18510 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | CPA2 | P48052 | 1/20 | 0.41 |
| ▸ | CPA4 | Q9UI42 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8642481 | 0.96 | ERAP2 (0.46) | ERAP2ERAP1IL1RNMMP8ACE2 | |
| SCHEMBL8641893 | 0.91 | HSD17B10 (0.45) | ERAP2ERAP1IL1RNMMP8CAPN1 | |
| SCHEMBL8645038 | 0.87 | HSD17B10 (0.46) | ERAP2ERAP1IL1RNMMP8MMP3 | |
| SCHEMBL5831419 | 0.79 | LMNA (0.47) | — | |
| SCHEMBL8641846 | 0.79 | MMP3 (0.36) | ERAP2ERAP1IL1RNMMP3LNPEP | |
| SCHEMBL7600979 | 0.76 | HSD17B10 (0.64) | ACE2MMP3 | |
| SCHEMBL8641877 | 0.75 | GPR88 (0.36) | ERAP2ERAP1IL1RNMMP8MMP3 | |
| SCHEMBL10869562 | 0.74 | GRIK1 (0.61) | ERAP2ERAP1IL1RNGRIK1CAPN1 | |
| SCHEMBL9506194 | 0.72 | ELANE (0.43) | ACE2ALDH1A1HPGDMMP3 | |
| SCHEMBL9506199 | 0.72 | ELANE (0.43) | ACE2ALDH1A1HPGDMMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0766687-B1 | PHOSPHINIC ACID DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 1998-08-05 | — | — | EP | disclosed |
| US-5739123-A | ANGIOTENSIN CONVERTING ENZYME INHIBITOR TREATING CARDIOVASCULAR DISEASES | ZAMBON GROUP S.P.A. (IT) | 1998-04-14 | — | — | US | disclosed |