Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | NRP1 | O14786 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 2/20 | 0.30 |
| ▸ | KDR | P35968 | 2/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637766 | 0.83 | SLC6A4 (0.36) | MMP12MMP13TSHRSLC6A4CCNE2 | |
| SCHEMBL8641982 | 0.80 | ERBB2 (0.36) | KDM4EUSP2HPGDTSHRCCNE2 | |
| SCHEMBL8637993 | 0.79 | RXFP1 (0.34) | MMP12MMP13SLC6A4CCNE2CDK4 | |
| SCHEMBL1097266 | 0.71 | CA2 (0.52) | MMP12MMP13SLC6A4 | |
| SCHEMBL5150566 | 0.68 | ALDH1A1 (0.39) | KDM4ETSHRCCNE2CDK4CCND1 | |
| SCHEMBL6438861 | 0.67 | RPS6KA3 (0.43) | KDM4EHPGDCCNE2CDK4CCND1 | |
| SCHEMBL3868483 | 0.65 | MAPK1 (0.36) | HPGDFFAR1FFAR4POLB | |
| SCHEMBL6622736 | 0.64 | MAPK14 (0.44) | CDK2CDK1KDR | |
| SCHEMBL6623323 | 0.64 | MAPK14 (0.44) | CDK2CDK1KDR | |
| SCHEMBL8642444 | 0.63 | GSK3B (0.45) | KDM4EKDRPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0856000-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLES FOR TREAMENT OF INFLAMMATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-05 | — | — | EP | disclosed |
| WO-1997013755-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLES FOR TREAMENT OF INFLAMMATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-17 | — | — | WO | disclosed |