Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | EEF2K | O00418 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FER | P16591 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641978 | 0.81 | ERBB2 (0.35) | ERBB2PGRCDK2EEF2KPLK4 | |
| SCHEMBL8645110 | 0.80 | MMP12 (0.36) | KDM4EUSP2HPGDTSHRCDK2 | |
| SCHEMBL13264873 | 0.70 | SLC6A4 (0.48) | KDM4EALOX5 | |
| SCHEMBL5150566 | 0.68 | ALDH1A1 (0.39) | KDM4ETSHRCDK2CCNE2CDK4 | |
| SCHEMBL8641979 | 0.64 | PTGS2 (0.45) | PGRALOX5 | |
| SCHEMBL6623323 | 0.64 | MAPK14 (0.44) | ALOX5CDK2EEF2KPLK4DAPK3 | |
| SCHEMBL6622736 | 0.64 | MAPK14 (0.44) | ALOX5CDK2EEF2KPLK4DAPK3 | |
| SCHEMBL8642444 | 0.64 | GSK3B (0.45) | KDM4ERETKDRGSK3B | |
| SCHEMBL14519409 | 0.62 | MAPK14 (0.46) | ALOX5PRKD3MAP4K4RETRPS6KB1 | |
| SCHEMBL8640607 | 0.62 | MAPK1 (0.73) | KDM4EHPGDRPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0856000-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLES FOR TREAMENT OF INFLAMMATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-05 | — | — | EP | disclosed |
| WO-1997013755-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLES FOR TREAMENT OF INFLAMMATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-17 | — | — | WO | disclosed |