Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171138 | 0.77 | ALDH1A1 (0.43) | LMNAKMT2AMEN1CYP3A4ALDH1A1 | |
| SCHEMBL8541154 | 0.76 | HPGD (0.47) | HPGDLMNAPOLBKMT2AALDH1A1 | |
| SCHEMBL15145044 | 0.76 | LMNA (0.58) | HPGDLMNAPOLBCYP3A4ALDH1A1 | |
| SCHEMBL8546503 | 0.75 | HPGD (0.34) | HPGDLMNAPOLBKMT2ACYP3A4 | |
| SCHEMBL6215960 | 0.71 | HPGD (0.53) | HPGDLMNAKMT2AMEN1CYP3A4 | |
| SCHEMBL2220329 | 0.71 | CYP3A4 (0.71) | HPGDLMNAKMT2AMEN1CYP3A4 | |
| SCHEMBL5458653 | 0.71 | LMNA (0.64) | HPGDLMNAPOLBKMT2ACYP3A4 | |
| SCHEMBL31663185 | 0.71 | LMNA (0.51) | HPGDLMNAPOLBCYP3A4ALDH1A1 | |
| SCHEMBL14552371 | 0.70 | POLB (0.61) | HPGDLMNAPOLBCYP3A4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8695507 | 0.70 | CYP3A4 (0.69) | HPGDLMNAKMT2AMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817782-A1 | PHENYL DERIVATIVES USEFUL AS ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-01-14 | — | — | EP | disclosed |