SCHEMBL864679

SCHEMBL864679

CC(C)OC(=O)N1CCC(Oc2ccc(-c3ccc(CC(NC(=O)OC(C)(C)C)C(=O)N4CCC(F)C4)c(F)c3)cn2)CC1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 8/20 0.40
LIPE Q05469 1/20 0.37
KMT2A Q03164 1/20 0.36
TRPV1 Q8NER1 1/20 0.36
DPP4 P27487 2/20 0.36
DPP8 Q6V1X1 1/20 0.36
DPP9 Q86TI2 1/20 0.36
DPP7 Q9UHL4 1/20 0.36
MAPK1 P28482 1/20 0.36
PIK3CD O00329 1/20 0.35
POLB P06746 1/20 0.35
P2RY12 Q9H244 1/20 0.35
SCN9A Q15858 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL864678 1.00 GPR119 (0.40) GPR119LIPEKMT2ATRPV1DPP4
SCHEMBL864677 1.00 GPR119 (0.40) GPR119LIPEKMT2ATRPV1DPP4
SCHEMBL10101176 0.92 DPP4 (0.37) GPR119KMT2ADPP4DPP8DPP9
SCHEMBL864976 0.92 DPP4 (0.37) GPR119KMT2ADPP4DPP8DPP9
SCHEMBL864975 0.92 DPP4 (0.37) GPR119KMT2ADPP4DPP8DPP9
SCHEMBL864977 0.92 DPP4 (0.37) GPR119KMT2ADPP4DPP8DPP9
SCHEMBL865760 0.91 GPR119 (0.41) GPR119KMT2ATRPV1DPP4DPP8
SCHEMBL865762 0.91 GPR119 (0.41) GPR119KMT2ATRPV1DPP4DPP8
SCHEMBL865761 0.91 GPR119 (0.41) GPR119KMT2ATRPV1DPP4DPP8
SCHEMBL864900 0.90 GPR119 (0.38) GPR119LIPEKMT2ATRPV1DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120077793-A1 Compounds for the Treatment of Metabolic Disorders PROSIDION LIMITED (GB) 2012-03-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120077793-A1 Compounds for the Treatment of Metabolic Disorders GPR119, GPR132, FFAR2 GPR119 1/4885LIPE 111/4885KMT2A 2799/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.