Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 6/20 | 0.50 |
| ▸ | CA2 | P00918 | 6/20 | 0.50 |
| ▸ | CA9 | Q16790 | 6/20 | 0.50 |
| ▸ | CA12 | O43570 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8647178 | 1.00 | LMNA (0.57) | LMNAKMT2APOLBALDH1A1CA1 | |
| SCHEMBL19477874 | 1.00 | LMNA (0.57) | LMNAKMT2APOLBALDH1A1CA1 | |
| SCHEMBL5148124 | 1.00 | LMNA (0.57) | LMNAKMT2APOLBALDH1A1CA1 | |
| SCHEMBL2338780 | 1.00 | LMNA (0.57) | LMNAKMT2APOLBALDH1A1CA1 | |
| SCHEMBL20643514 | 1.00 | LMNA (0.57) | LMNAKMT2APOLBALDH1A1CA1 | |
| SCHEMBL10036857 | 1.00 | LMNA (0.57) | LMNAKMT2APOLBALDH1A1CA1 | |
| SCHEMBL19477779 | 1.00 | LMNA (0.57) | LMNAKMT2APOLBALDH1A1CA1 | |
| SCHEMBL22537923 | 1.00 | LMNA (0.57) | LMNAKMT2APOLBALDH1A1CA1 | |
| SCHEMBL21762059 | 1.00 | LMNA (0.57) | LMNAKMT2APOLBALDH1A1CA1 | |
| SCHEMBL3986108 | 1.00 | LMNA (0.57) | LMNAKMT2APOLBALDH1A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052134-B1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | MERCK SHARP & DOHME (US) | 2021-05-05 | — | — | EP | disclosed |
| US-20180110863-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2018-04-26 | — | — | US | disclosed |
| EP-3280450-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | Merck Sharp & Dohme Corp. (US) | 2018-02-14 | — | — | EP | disclosed |
| US-9889205-B2 | Glucose-responsive insulin conjugates | MERCK SHARP & DOHME CORP. (US) | 2018-02-13 | — | — | US | disclosed |
| US-20160303244-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2016-10-20 | — | — | US | disclosed |
| WO-2016164288-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2016-10-13 | — | — | WO | disclosed |
| US-9427475-B2 | Glucose-responsive insulin conjugates | MERCK SHARP & DOHME CORP. (US) | 2016-08-30 | — | — | US | disclosed |
| US-20150105317-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | MERCK SHARP & DOHME LLC | 2015-04-16 | — | — | US | disclosed |
| US-5756712-A | REPLACING THE ETHER OXYGEN LINKAGE OF OLIGOSACCHARIDES WITH A PEPTIDE LINK, WHERE THE NITROGEN ATOM IS LINKED TO THE ANOMERIC CARBON ATOM OF THE SUGAR | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0553297-B1 | PROCESS FOR THE PREPARATION OF GLYCOSYL PHOSPHATE TRIESTERS | DU PONT (US) | 1995-01-25 | — | — | EP | disclosed |
| US-5288859-A | Reacting metal azide with glycosyl phosphate triester | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| EP-0553297-A1 | PROCESS FOR THE PREPARATION OF GLYCOSYL PHOSPHATE TRIESTERS. | DU PONT (US) | 1993-08-04 | — | — | EP | disclosed |
| WO-1992009612-A1 | PROCESS FOR THE PREPARATION OF GLYCOSYL PHOSPHATE TRIESTERS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-06-11 | — | — | WO | disclosed |
| US-5095123-A | Phosphorylation | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-03-10 | — | — | US | disclosed |
| US-4792615-A | HYDROLYSIS OF A-DIHYDROPOLYPRENYL DICHLOROPHOSPHATE WITH ALKALI OR ALKALINE EARTH METAL HYDROXIDE; POLYISOPRENE | NAKAGAWA NAOSHI (JP) | 1988-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180110863-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | GPR119, INSR, IRS1 | LMNA 3810/4885KMT2A 2547/4885POLB 4628/4885 |
| US-20150105317-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | GPR119, INSR, IRS1 | LMNA 3539/4885KMT2A 2821/4885POLB 4705/4885 |
| US-20160303244-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | GPR119, INSR, IRS1 | LMNA 3539/4885KMT2A 2821/4885POLB 4705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.