Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | PPIA | P62937 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29482981 | 0.79 | MEN1 (0.41) | DRD2MEN1MAPK1KMT2ACTSL | |
| SCHEMBL4463790 | 0.78 | DRD2 (0.33) | DRD2MEN1MAPK1KMT2ACTSL | |
| SCHEMBL12440624 | 0.77 | RORC (0.37) | DRD2MEN1MAPK1KMT2ACACNA1H | |
| SCHEMBL31233594 | 0.75 | MEN1 (0.39) | DRD2MEN1MAPK1KMT2ACTSL | |
| SCHEMBL6922861 | 0.75 | MEN1 (0.39) | DRD2MEN1MAPK1KMT2ACTSL | |
| SCHEMBL29290043 | 0.75 | DRD2 (0.38) | DRD2MEN1MAPK1KMT2ACTSL | |
| SCHEMBL28049727 | 0.74 | DRD2 (0.34) | DRD2MEN1MAPK1KMT2ACTSL | |
| SCHEMBL1670965 | 0.74 | GAA (0.38) | DRD2MEN1MAPK1KMT2ACTSL | |
| SCHEMBL23011175 | 0.73 | DRD2 (0.36) | DRD2MEN1MAPK1KMT2ACTSL | |
| SCHEMBL14820282 | 0.73 | MEN1 (0.37) | DRD2MEN1MAPK1KMT2ACACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854268-A | Azetidine, pyrrolidine and piperidine derivatives | MERCK SHARP & DOHME, LTD. (GB) | 1998-12-29 | — | — | US | disclosed |