Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | PPIA | P62937 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28049727 | 0.91 | DRD2 (0.34) | DRD2CACNA1HMEN1MAPK1KMT2A | |
| SCHEMBL28189059 | 0.84 | CYP4F2 (0.33) | DRD2MEN1MAPK1KMT2ACTSK | |
| SCHEMBL21777669 | 0.82 | EPHX2 (0.40) | USP2EPHX2 | |
| SCHEMBL142219 | 0.80 | MEN1 (0.39) | MEN1MAPK1KMT2ACTSKGHSR | |
| SCHEMBL1003478 | 0.80 | EPHX2 (0.34) | DRD2MEN1MAPK1KMT2ACTSK | |
| SCHEMBL391708 | 0.79 | USP2 (0.45) | MEN1KMT2AUSP2EPHX2 | |
| SCHEMBL8647697 | 0.78 | DRD2 (0.40) | DRD2CACNA1HMEN1MAPK1KMT2A | |
| SCHEMBL4522936 | 0.77 | HPGD (0.39) | MEN1KMT2AUSP2EPHX2 | |
| SCHEMBL76966 | 0.77 | BTK (0.38) | MEN1MAPK1KMT2AGHSRBTK | |
| SCHEMBL202837 | 0.77 | BTK (0.38) | MEN1MAPK1KMT2AGHSRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476663-B2 | Substituted thiophene carboxamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-13 | — | — | US | disclosed |
| US-20050277628-A1 | Substituted thiophene carboxamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277628-A1 | Substituted thiophene carboxamides | OTC, SLC22A8, DDC | DRD2 1782/4885CACNA1H 2187/4885MEN1 2017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.