Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | DDO | Q99489 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30838562 | 0.82 | KDM4E (0.49) | DAOBRD4DDOKDM4ETSHR | |
| SCHEMBL828487 | 0.82 | BRD4 (0.59) | DAOBRD4DDOKDM4ETSHR | |
| SCHEMBL30638395 | 0.80 | DAO (0.50) | DAOBRD4DDOKDM4ETSHR | |
| SCHEMBL29875597 | 0.79 | ALOX5 (0.57) | DAOBRD4DDOKDM4ETSHR | |
| SCHEMBL1767751 | 0.79 | ALOX5 (0.57) | DAOBRD4DDOKDM4ETSHR | |
| Hydrochloric Acid SCHEMBL22159198 | 0.78 | BRD4 (0.54) | DAOBRD4DDOKDM4ETSHR | |
| SCHEMBL5475936 | 0.77 | KDM4E (0.48) | DAOBRD4DDOKDM4ETSHR | |
| SCHEMBL20621731 | 0.76 | BRD4 (0.53) | DAOBRD4DDOKDM4ETSHR | |
| SCHEMBL22035463 | 0.75 | BRD4 (0.51) | DAOBRD4DDOKDM4ETSHR | |
| SCHEMBL31394 | 0.75 | KDM4E (0.59) | DAOBRD4DDOKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710139-A | Heterocyclic compounds | ASTRA AB (SE) | 1998-01-20 | — | — | US | disclosed |
| EP-0736032-A1 | HETEROCYCLIC COMPOUNDS | Astra Aktiebolag (SE) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995017410-A1 | HETEROCYCLIC COMPOUNDS | ASTRA AKTIEBOLAG (SE) | 1995-06-29 | — | — | WO | disclosed |