SCHEMBL8648702

SCHEMBL8648702

CCCCCCCCCCOc1c(C)cc(Br)cc1C

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.54
KMT2A Q03164 4/20 0.54
KDM4E B2RXH2 2/20 0.54
ALDH1A1 P00352 2/20 0.54
CYP1A2 P05177 1/20 0.54
CYP2D6 P10635 1/20 0.54
THRA P10827 5/20 0.51
THRB P10828 5/20 0.51
S1PR2 O95136 3/20 0.46
S1PR1 P21453 3/20 0.46
S1PR3 Q99500 3/20 0.46
LPAR2 Q9HBW0 3/20 0.46
ESR1 P03372 2/20 0.39
NR5A1 Q13285 1/20 0.39
PLA2G2A P14555 1/20 0.39
TSHR P16473 1/20 0.39
TDP1 Q9NUW8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12634965 1.00 MEN1 (0.54) MEN1KMT2AKDM4EALDH1A1CYP1A2
SCHEMBL22246031 0.88 MEN1 (0.44) MEN1KMT2AKDM4EALDH1A1CYP1A2
SCHEMBL5417671 0.87 S1PR2 (0.49) MEN1KMT2AKDM4EALDH1A1CYP1A2
SCHEMBL27458128 0.86 KMT2A (0.50) MEN1KMT2AKDM4EALDH1A1CYP1A2
SCHEMBL6132273 0.85 KDM4E (0.54) MEN1KMT2AKDM4EALDH1A1CYP1A2
SCHEMBL6132790 0.85 MEN1 (0.54) MEN1KMT2AKDM4EALDH1A1CYP1A2
SCHEMBL12431881 0.84 THRA (0.54) MEN1KMT2AKDM4EALDH1A1THRA
SCHEMBL11956145 0.84 THRA (0.54) MEN1KMT2AKDM4EALDH1A1THRA
SCHEMBL19594430 0.84 THRA (0.54) MEN1KMT2AKDM4EALDH1A1CYP1A2
SCHEMBL20696027 0.82 THRA (0.61) MEN1KMT2AALDH1A1THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0702668-B1 DISCOTIC COMPOUNDS FOR USE IN LIQUID CRYSTAL MIXTURES SECR DEFENCE BRIT (GB) 1998-08-26 EP disclosed
US-5750050-A Discotic compounds for use in liquid crystal mixtures SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE U.K. OF GT. BRITAIN AND N. IRELAND OF DEFENCE EVALUATION RESEARCH AGENCY, DRA (GB) 1998-05-12 US disclosed
EP-0702668-A1 DISCOTIC COMPOUNDS FOR USE IN LIQUID CRYSTAL MIXTURES The Secretary of St. for Def. in her Britannic Maj. Governm of the Un. Kingdom of Gr. Brit. and N. Ireland (GB) 1996-03-27 EP disclosed
WO-1994029263-A1 DISCOTIC COMPOUNDS FOR USE IN LIQUID CRYSTAL MIXTURES THE SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND (GB) 1994-12-22 WO disclosed