Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.69 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.66 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.66 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.64 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.64 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.60 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13777343 | 0.86 | MEN1 (0.55) | LMNACYP1A2CYP2C9HIF1ACYP2D6 | |
| SCHEMBL13777321 | 0.83 | PLA2G2A (0.52) | LMNACYP1A2CYP2C9HIF1ACYP2D6 | |
| SCHEMBL1082631 | 0.82 | HIF1A (1.00) | LMNACYP1A2CYP2C9HIF1ACYP2D6 | |
| SCHEMBL5644884 | 0.82 | LMNA (0.77) | LMNACYP1A2CYP2C9HIF1ACYP2D6 | |
| SCHEMBL10876035 | 0.81 | AKR1C3 (0.76) | LMNACYP1A2CYP2C9HIF1ACYP2D6 | |
| SCHEMBL5646126 | 0.81 | LMNA (0.76) | LMNACYP1A2CYP2C9HIF1ACYP2D6 | |
| Hydrochloric Acid SCHEMBL8646699 | 0.81 | HIF1A (0.98) | LMNACYP1A2CYP2C9HIF1ACYP2D6 | |
| SCHEMBL8648170 | 0.80 | PLA2G2A (0.84) | LMNACYP1A2CYP2C9HIF1ACYP2D6 | |
| SCHEMBL7963016 | 0.80 | PLA2G2A (1.00) | LMNACYP1A2CYP2C9HIF1ANPSR1 | |
| SCHEMBL11859825 | 0.80 | LMNA (0.71) | LMNACYP1A2CYP2C9HIF1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0746544-B1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMA INC (US) | 1998-09-09 | — | — | EP | disclosed |