Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 13/20 | 0.84 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.64 |
| ▸ | RGS12 | O14924 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8298845 | 0.90 | PLA2G2A (0.78) | PLA2G2APLA2G1BLMNACYP1A2CYP2C9 | |
| SCHEMBL8291787 | 0.89 | PLA2G2A (1.00) | PLA2G2A | |
| SCHEMBL8301171 | 0.87 | PLA2G2A (0.74) | PLA2G2APLA2G1BLMNACYP1A2CYP2C9 | |
| SCHEMBL7963016 | 0.86 | PLA2G2A (1.00) | PLA2G2APLA2G1BLMNACYP1A2CYP2C9 | |
| SCHEMBL8296778 | 0.86 | PLA2G2A (0.94) | PLA2G2A | |
| SCHEMBL7952654 | 0.84 | PLA2G2A (0.82) | PLA2G2APLA2G1BLMNACYP1A2CYP2C9 | |
| SCHEMBL9371452 | 0.84 | PLA2G2A (0.82) | PLA2G2APLA2G1BLMNACYP1A2CYP2C9 | |
| SCHEMBL14446495 | 0.81 | LMNA (0.89) | PLA2G2APLA2G1BLMNACYP1A2CYP2C9 | |
| SCHEMBL8649132 | 0.80 | LMNA (0.69) | PLA2G2APLA2G1BLMNACYP1A2CYP2C9 | |
| SCHEMBL7963230 | 0.80 | PLA2G2A (0.86) | PLA2G2APLA2G1BLMNACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0746544-B1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMA INC (US) | 1998-09-09 | — | — | EP | disclosed |