Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 6/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616548 | 0.84 | ALDH1A1 (0.41) | ALDH1A1TSHRPOLBMAPTPKM | |
| SCHEMBL1647691 | 0.78 | — | — | |
| SCHEMBL4155788 | 0.75 | CHRM2 (0.45) | ALDH1A1TSHRPOLBHPGDMAPT | |
| SCHEMBL13680858 | 0.75 | ALDH1A1 (0.35) | ALDH1A1TSHRPOLBHPGDMAPT | |
| SCHEMBL13680861 | 0.75 | ALDH1A1 (0.35) | ALDH1A1TSHR | |
| SCHEMBL27876267 | 0.73 | — | — | |
| SCHEMBL25183771 | 0.71 | HIF1A (0.41) | ALDH1A1TSHR | |
| SCHEMBL13543542 | 0.71 | — | — | |
| SCHEMBL8645128 | 0.71 | ALDH1A1 (0.32) | ALDH1A1TSHR | |
| SCHEMBL25180381 | 0.70 | EPHX2 (0.46) | ALDH1A1TSHRHPGDMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-5808101-A | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents | ALLERGAN (US) | 1998-09-15 | — | — | US | disclosed |
| US-5710288-A | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents | ALLERGAN (US) | 1998-01-20 | — | — | US | disclosed |