Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | NOS3 | P29474 | 4/20 | 0.38 |
| ▸ | NOS2 | P35228 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14870745 | 0.79 | HTR2A (0.55) | ACHESMN1; SMN2HRH1HRH4NOS3 | |
| SCHEMBL29439854 | 0.79 | HTR2A (0.55) | ACHESMN1; SMN2HRH1HRH4NOS3 | |
| SCHEMBL1093558 | 0.77 | ACHE (0.59) | ACHESMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL7338494 | 0.77 | NOS3 (0.44) | ACHESMN1; SMN2HRH1HRH4NOS3 | |
| SCHEMBL30737574 | 0.77 | ACHE (0.59) | ACHESMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL32679178 | 0.77 | ACHE (0.59) | ACHESMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL32679177 | 0.77 | ACHE (0.59) | ACHESMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL8097427 | 0.77 | ACHE (0.39) | ACHESMN1; SMN2HRH1HRH4NOS3 | |
| SCHEMBL8336431 | 0.77 | NOS3 (0.44) | ACHESMN1; SMN2HRH1HRH4NOS3 | |
| SCHEMBL7998826 | 0.77 | ACHE (0.59) | ACHESMN1; SMN2TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555036-B1 | Antitumor compositions and methods of treatment | LILLY CO ELI (US) | 1998-09-09 | — | — | EP | disclosed |
| US-5262440-A | Treatment of neoplasms | ELI LILLY AND COMPANY (US) | 1993-11-16 | — | — | US | disclosed |
| US-5254582-A | Using n-((3,4-dichlorophenyl)amino)carbonyl)-2,3-dihydro-benzofuran-5-sulfonamide | ELI LILLY AND COMPANY (US) | 1993-10-19 | — | — | US | disclosed |
| EP-0555036-A2 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-08-11 | — | — | EP | disclosed |
| EP-0546763-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-06-16 | — | — | EP | disclosed |