SCHEMBL8649490

SCHEMBL8649490

OCCCc1ccc(O)c(-n2nc3ccc(Cl)cc3n2)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 4/20 0.42
IGF1R P08069 3/20 0.42
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
LMNA P02545 1/20 0.40
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
AKR1B1 P15121 1/20 0.38
RXFP1 Q9HBX9 1/20 0.36
CYP11B1 P15538 1/20 0.36
CYP11B2 P19099 1/20 0.36
KDM4E B2RXH2 3/20 0.35
ALDH1A1 P00352 2/20 0.35
POLB P06746 1/20 0.35
HPGD P15428 1/20 0.35
MAPK1 P28482 1/20 0.35
HSD17B10 Q99714 1/20 0.35
BACE1 P56817 2/20 0.35
NUDT1 P36639 1/20 0.35
MAPT P10636 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30240998 0.96 ALOX15 (0.44) ALOX15IGF1RNPC1RAB9ALMNA
SCHEMBL28755473 0.96 ALOX15 (0.44) ALOX15IGF1RNPC1RAB9ALMNA
SCHEMBL7566832 0.92 MAPT (0.42) ALOX15IGF1RNPC1RAB9ALMNA
SCHEMBL2589692 0.89 NPC1 (0.42) ALOX15IGF1RNPC1RAB9ALMNA
SCHEMBL9240944 0.88 IGF1R (0.43) ALOX15IGF1RNPC1RAB9ALMNA
SCHEMBL13699403 0.87 NPC1 (0.43) ALOX15IGF1RNPC1RAB9ALMNA
SCHEMBL31252564 0.86 KAT8 (0.43) ALOX15IGF1RNPC1RAB9ALMNA
SCHEMBL9638776 0.86 NPC1 (0.43) ALOX15IGF1RNPC1RAB9ALMNA
SCHEMBL75064 0.85 LMNA (0.55) ALOX15IGF1RNPC1RAB9ALMNA
SCHEMBL30240898 0.85 LMNA (0.55) ALOX15IGF1RNPC1RAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0131468-B1 ULTRAVIOLET ABSORBING POLYMERS COMPRISING 2-HYDROXY-5-ACRYLYLOXALKYLPHENYL-2H-BENZOTRIAZOLES IOLAB CORPORATION (US) 1990-01-17 EP claimed
US-4611061-A 2'-hydroxy-5'-(hydroxyalkyl)phenyl-2H-benzotriazoles IOLAB CORPORATION (US) 1986-09-09 US claimed
EP-0131468-A2 Ultraviolet absorbing polymers comprising 2-hydroxy-5-acrylyloxalkylphenyl-2H-benzotriazoles IOLAB CORPORATION (US) 1985-01-16 EP claimed
CN-100528989-C Anion electroplating paint and finished articles KANSAI PAINT CO LTD (JP) 2009-08-19 CN disclosed
CN-1673295-A Anion electroplating paint and finished articles KANSAI PAINT CO LTD (JP) 2005-09-28 CN disclosed
US-5814438-A Benzotriazole-based novel UV absorbers and photographic elements containing them EASTMAN KODAK COMPANY (US) 1998-09-29 US disclosed
US-5675015-A Process for the preparation of benzotriazole derivatives EASTMAN KODAK COMPANY (US) 1997-10-07 US disclosed
EP-0131468-B1 ULTRAVIOLET ABSORBING POLYMERS COMPRISING 2-HYDROXY-5-ACRYLYLOXALKYLPHENYL-2H-BENZOTRIAZOLES IOLAB CORPORATION (US) 1990-01-17 EP disclosed
US-4611061-A 2'-hydroxy-5'-(hydroxyalkyl)phenyl-2H-benzotriazoles IOLAB CORPORATION (US) 1986-09-09 US disclosed
EP-0131468-A2 Ultraviolet absorbing polymers comprising 2-hydroxy-5-acrylyloxalkylphenyl-2H-benzotriazoles IOLAB CORPORATION (US) 1985-01-16 EP disclosed