Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8650338 | 0.94 | POLB (0.38) | POLBMAPTKDM4ECCNB2CDK1 | |
| SCHEMBL8649374 | 0.79 | POLB (0.44) | POLBMAPTKDM4ECDK1GAA | |
| SCHEMBL8649379 | 0.73 | POLB (0.41) | POLBMAPTKDM4EGSK3BALDH1A1 | |
| SCHEMBL8647457 | 0.70 | LMNA (0.33) | POLBMAPTTACR1TACR3HPGD | |
| SCHEMBL8645900 | 0.69 | MAPT (0.34) | POLBMAPTTACR1TACR3HDAC1 | |
| SCHEMBL8647005 | 0.68 | LMNA (0.34) | POLBMAPTHDAC1HDAC6 | |
| SCHEMBL7342604 | 0.68 | CRBN (0.47) | MAPTCCNB2CDK1CCNB1GSK3B | |
| SCHEMBL8645908 | 0.68 | MAPT (0.35) | POLBMAPTTACR1TACR3 | |
| SCHEMBL8647012 | 0.67 | LMNA (0.33) | POLBMAPTKDM4ETACR1TACR3 | |
| SCHEMBL7439109 | 0.66 | BRD4 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843972-A | Heterocyclic β-adrenergic agonists | PFIZER INC. (US) | 1998-12-01 | — | — | US | disclosed |
| EP-0801060-A1 | Heterocyclic Beta-3 Adrenergenic Agonists | PFIZER INC. (US) | 1997-10-15 | — | — | EP | disclosed |