Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | FSHR | P23945 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 9/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8645900 | 0.95 | MAPT (0.34) | MAPTPTGS1AKR1C3AKR1C2NOTUM | |
| SCHEMBL8648264 | 0.89 | MAPT (0.33) | MAPTPTGS1AKR1C3AKR1C2TP53 | |
| SCHEMBL8645861 | 0.88 | MAPT (0.44) | MAPTTP53LMNAPOLB | |
| SCHEMBL8647457 | 0.86 | LMNA (0.33) | MAPTPTGS1AKR1C3AKR1C2NOTUM | |
| SCHEMBL8647012 | 0.85 | LMNA (0.33) | MAPTPTGS1AKR1C3AKR1C2TP53 | |
| SCHEMBL8647266 | 0.84 | KMT2A (0.37) | LMNATACR1TACR3 | |
| SCHEMBL8645856 | 0.84 | MAPT (0.40) | MAPTTP53LMNAPOLB | |
| SCHEMBL8647005 | 0.82 | LMNA (0.34) | MAPTNOTUMTP53LMNAPOLB | |
| SCHEMBL8644950 | 0.82 | AMPD2 (0.38) | MAPTPOLBTACR1TACR3 | |
| SCHEMBL8645683 | 0.81 | HSD17B3 (0.37) | MAPTNOTUMTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843972-A | Heterocyclic β-adrenergic agonists | PFIZER INC. (US) | 1998-12-01 | — | — | US | disclosed |
| EP-0801060-A1 | Heterocyclic Beta-3 Adrenergenic Agonists | PFIZER INC. (US) | 1997-10-15 | — | — | EP | disclosed |