SCHEMBL8650547

SCHEMBL8650547

CCC(c1ccc(Cl)cc1)C(CC(=O)O)C(=O)NC(C(=O)OC)C(C)(C)C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.40
KMT2A Q03164 3/20 0.40
CYP2C9 P11712 3/20 0.40
MEN1 O00255 2/20 0.40
CYP2D6 P10635 2/20 0.40
CYP2C19 P33261 2/20 0.40
FDFT1 P37268 1/20 0.38
MMP2 P08253 3/20 0.37
MMP3 P08254 3/20 0.37
CYP26A1 O43174 1/20 0.36
MMP1 P03956 1/20 0.36
CNR1 P21554 3/20 0.36
CNR2 P34972 2/20 0.36
GABBR2 O75899 3/20 0.36
GABBR1 Q9UBS5 3/20 0.36
LMNA P02545 2/20 0.36
CYP3A4 P08684 1/20 0.36
ADORA3 P0DMS8 1/20 0.36
NFKB1 P19838 1/20 0.36
DRD3 P35462 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8663575 0.89 MMP3 (0.46) L3MBTL1MMP2MMP3MMP1
SCHEMBL8652782 0.88 CYP2C9 (0.43) KMT2ACYP2C9MEN1CYP2D6CYP2C19
SCHEMBL8650858 0.77 MMP3 (0.55) MMP2MMP3MMP1
SCHEMBL8665565 0.77 MMP3 (0.56) MMP2MMP3MMP1
SCHEMBL8665728 0.77 MMP3 (0.44) MMP2MMP3MMP1
SCHEMBL8650550 0.73 MMP2 (0.62) MMP2MMP3
SCHEMBL6417772 0.69 MMP3 (0.48) MMP2MMP3MMP1
SCHEMBL7764984 0.69 MMP3 (0.48) MMP2MMP3MMP1
SCHEMBL6412000 0.69 FCER2 (0.44) MMP2MMP3MMP1
SCHEMBL5702667 0.68 CYP2C9 (0.43) KMT2ACYP2C9MEN1CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0712390-B1 SUCCINAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS GELATINASE AND COLLAGENASE INHIBITORS CELLTECH THERAPEUTICS LTD (GB) 1998-12-09 EP disclosed
US-5827890-A ANGIOGENESIS INHIBITORS CELLTECH THERAPEUTICS LTD. (GB) 1998-10-27 US disclosed
WO-1995004033-A1 SUCCINAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS GELATINASE AND COLLAGENASE INHIBITORS CELLTECH LIMITED (GB) 1995-02-09 WO disclosed