Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | THRB | P10828 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | GPR132 | Q9UNW8 | 6/20 | 0.50 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.50 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8650796 | 1.00 | ALDH1A1 (0.69) | ALDH1A1LMNATHRBSMN1; SMN2MEN1 | |
| SCHEMBL14021666 | 0.88 | MEN1 (0.84) | ALDH1A1LMNATHRBSMN1; SMN2MEN1 | |
| SCHEMBL8645546 | 0.85 | ALDH1A1 (0.59) | ALDH1A1LMNATHRBSMN1; SMN2MEN1 | |
| SCHEMBL8643121 | 0.85 | ALDH1A1 (0.59) | ALDH1A1LMNATHRBSMN1; SMN2MEN1 | |
| SCHEMBL8643115 | 0.85 | ALDH1A1 (0.59) | ALDH1A1LMNATHRBSMN1; SMN2MEN1 | |
| SCHEMBL27554954 | 0.83 | ALDH1A1 (0.64) | ALDH1A1LMNATHRBSMN1; SMN2MEN1 | |
| SCHEMBL8645503 | 0.82 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8645501 | 0.82 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8649361 | 0.82 | KMT2A (0.50) | ALDH1A1LMNATHRBSMN1; SMN2MEN1 | |
| SCHEMBL8649367 | 0.82 | KMT2A (0.50) | ALDH1A1LMNATHRBSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861831-A1 | HETEROARYL-SUBSTITUTED ACRYLOYLGUANIDINE DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-09-02 | — | — | EP | disclosed |