Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GPR132 | Q9UNW8 | 8/20 | 0.46 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.46 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8647067 | 0.96 | ALDH1A1 (0.54) | ALDH1A1LMNATHRBSMN1; SMN2MEN1 | |
| SCHEMBL8649085 | 0.88 | LMNA (0.44) | ALDH1A1LMNATHRBSMN1; SMN2MEN1 | |
| SCHEMBL8647072 | 0.86 | ALDH1A1 (0.52) | ALDH1A1LMNATHRBSMN1; SMN2MEN1 | |
| SCHEMBL8650792 | 0.85 | ALDH1A1 (0.69) | ALDH1A1LMNATHRBSMN1; SMN2MEN1 | |
| SCHEMBL8650796 | 0.85 | ALDH1A1 (0.69) | ALDH1A1LMNATHRBSMN1; SMN2MEN1 | |
| SCHEMBL8648534 | 0.84 | CYP1A1 (0.55) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL8644166 | 0.84 | CYP1A1 (0.52) | ALDH1A1LMNATHRBMEN1KMT2A | |
| SCHEMBL27520778 | 0.84 | RAB9A (0.42) | ALDH1A1LMNATHRBSMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL8667384 | 0.83 | RAB9A (0.41) | ALDH1A1LMNATHRBSMN1; SMN2MEN1 | |
| SCHEMBL8645267 | 0.83 | CYP1A1 (0.47) | ALDH1A1LMNAMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861831-A1 | HETEROARYL-SUBSTITUTED ACRYLOYLGUANIDINE DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-09-02 | — | — | EP | disclosed |