Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | P4HB | P07237 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 4/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8644166 | 0.85 | CYP1A1 (0.52) | MEN1KMT2AP4HBKDM4EGAA | |
| SCHEMBL8647943 | 0.84 | CYP1A2 (0.47) | MEN1KMT2ANAMPTALOX15NPSR1 | |
| SCHEMBL8645267 | 0.83 | CYP1A1 (0.47) | MEN1KMT2AKDM4EPOLBGAA | |
| SCHEMBL8645512 | 0.82 | TSHR (0.54) | TSHRMEN1KMT2AP4HBTBXAS1 | |
| SCHEMBL8645516 | 0.82 | TSHR (0.54) | TSHRMEN1KMT2AP4HBTBXAS1 | |
| SCHEMBL8648599 | 0.81 | ALDH1A1 (0.42) | MEN1KMT2AP4HBRECQLBRAF | |
| SCHEMBL8648534 | 0.81 | CYP1A1 (0.55) | TSHRMEN1KMT2APOLBMAPT | |
| SCHEMBL8649085 | 0.80 | LMNA (0.44) | MEN1KMT2ARECQLBRAFMAPT | |
| SCHEMBL8646691 | 0.80 | CYP1A1 (0.47) | KMT2AP4HBNAMPTKDM4EGAA | |
| SCHEMBL8650818 | 0.80 | NAMPT (0.46) | NAMPTBRAFVNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861831-A1 | HETEROARYL-SUBSTITUTED ACRYLOYLGUANIDINE DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-09-02 | — | — | EP | disclosed |