Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 2/20 | 0.47 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | TACR2 | P21452 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560062 | 1.00 | LPL (0.47) | LPLLIPGPPARADRD2OPRM1 | |
| SCHEMBL8564542 | 0.99 | LPL (0.46) | LPLLIPGPPARADRD2OPRM1 | |
| SCHEMBL8564062 | 0.94 | LPL (0.40) | LPLLIPGPPARADRD2OPRM1 | |
| SCHEMBL8565354 | 0.89 | DRD2 (0.36) | DRD2OPRM1DRD3OPRD1OPRK1 | |
| SCHEMBL2464423 | 0.75 | LPL (0.54) | LPLLIPGPPARADRD2OPRM1 | |
| SCHEMBL9835921 | 0.74 | LPL (0.54) | LPLLIPGPPARAPPARG | |
| SCHEMBL22795880 | 0.73 | LPL (0.53) | LPLLIPGPPARADRD2OPRM1 | |
| SCHEMBL27657598 | 0.73 | LPL (0.53) | LPLLIPGPPARADRD2OPRM1 | |
| Hydrochloric Acid SCHEMBL28356096 | 0.73 | PTGS2 (0.63) | LPLLIPGDRD2OPRM1DRD3 | |
| SCHEMBL10235993 | 0.73 | LPL (0.53) | LPLLIPGPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0568898-B1 | Benzothiepine-, benzothiopyrane- and benzothiophenyle derivatives, their preparation and use as medicine | HOFFMANN LA ROCHE (CH) | 1998-04-01 | — | — | EP | disclosed |
| EP-0568898-A1 | Benzothiepine-, benzothiopyrane- and benzothiophenyle derivatives, their preparation and use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1993-11-10 | — | — | EP | disclosed |