Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 2/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8907367 | 0.90 | SHMT1 (0.48) | SHMT1SHMT2P2RX7KMT2ASIGMAR1 | |
| SCHEMBL8657143 | 0.89 | P2RX7 (0.37) | P2RX7KMT2AATMANO1EPHX2 | |
| SCHEMBL8657000 | 0.89 | SHMT1 (0.40) | SHMT1SHMT2P2RX7SIGMAR1NPC1 | |
| SCHEMBL8907160 | 0.89 | NPC1 (0.40) | P2RX7KMT2AATMNPC1RAB9A | |
| SCHEMBL8652492 | 0.87 | FFAR4 (0.40) | SHMT1SHMT2P2RX7SIGMAR1ANO1 | |
| SCHEMBL6474818 | 0.86 | MEN1 (0.41) | SHMT1SHMT2P2RX7KMT2ASIGMAR1 | |
| SCHEMBL8650591 | 0.86 | SHMT1 (0.46) | SHMT1SHMT2P2RX7KMT2AFABP4 | |
| SCHEMBL8654468 | 0.86 | SHMT1 (0.38) | SHMT1SHMT2P2RX7SIGMAR1EPHX2 | |
| SCHEMBL8654098 | 0.86 | SHMT1 (0.38) | SHMT1SHMT2P2RX7SIGMAR1EPHX2 | |
| SCHEMBL8652410 | 0.85 | SHMT1 (0.43) | SHMT1SHMT2P2RX7KMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847211-A | Substituted 1H-3-Aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1998-12-08 | — | — | US | disclosed |
| US-5622917-A | PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-04-22 | — | — | US | disclosed |