Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PARG | Q86W56 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.38 |
| ▸ | DAO | P14920 | 4/20 | 0.37 |
| ▸ | DDO | Q99489 | 2/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19126568 | 0.77 | DAO (0.64) | PARGDAODDOKDM4E | |
| SCHEMBL26608351 | 0.77 | DAO (0.64) | MAPK1DAODDOKDM4E | |
| SCHEMBL30593196 | 0.77 | DAO (0.64) | MAPK1DAODDOKDM4E | |
| SCHEMBL31378692 | 0.76 | GRIN2D (0.39) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL791472 | 0.74 | GRIN2D (0.44) | MAPK1PARGGRIN2DGRIN3BGRIN1 | |
| SCHEMBL123451 | 0.73 | KDM4E (0.58) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL19207400 | 0.73 | GRIN2D (0.56) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL463673 | 0.72 | GRIN2D (0.52) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL18548573 | 0.72 | CYP19A1 (0.49) | MAPK1PARGDAO | |
| SCHEMBL16627567 | 0.72 | METAP2 (0.46) | DAODDO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640612-B1 | Novel derivatives from 2-(1H)-quinolinone, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-04-22 | — | — | EP | disclosed |
| US-5646132-A | TREATING CEREBRAL ISCHEMIA | ADIR ET COMPAGNIE (FR) | 1997-07-08 | — | — | US | disclosed |
| US-5536709-A | INHIBITORS OF HYPERACTIVATION OF EXCITATORY AMINO ACIDS | ADIR ET COMPAGNIE (FR) | 1996-07-16 | — | — | US | disclosed |
| EP-0640612-A1 | Novel derivatives from 2-(1H)-quinolinone, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-03-01 | — | — | EP | disclosed |