Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 8/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8645192 | 0.87 | MEN1 (0.48) | MEN1KMT2ANPSR1TMEM97SIGMAR1 | |
| SCHEMBL8645188 | 0.87 | MEN1 (0.48) | MEN1KMT2ANPSR1TMEM97SIGMAR1 | |
| SCHEMBL8656896 | 0.86 | MEN1 (0.47) | MEN1KMT2ANPSR1TMEM97SIGMAR1 | |
| SCHEMBL8655361 | 0.84 | HTR2A (0.46) | MEN1KMT2AHTR2AHTR2CHTR2B | |
| SCHEMBL8654687 | 0.83 | MEN1 (0.43) | MEN1KMT2ANPSR1TMEM97SIGMAR1 | |
| SCHEMBL8654691 | 0.83 | MEN1 (0.43) | MEN1KMT2ANPSR1TMEM97SIGMAR1 | |
| SCHEMBL8658395 | 0.80 | MAOB (0.52) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL13855695 | 0.80 | GFER (0.44) | MEN1KMT2ANPSR1MAPTHTT | |
| SCHEMBL7544832 | 0.77 | MTNR1A (0.50) | NPSR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10151525 | 0.76 | MAOA (0.51) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858453-A1 | 5-(ACETAMIDOMETHYL)-3-ARYLDIHYDROFURAN-2-ONE AND TETRAHYDROFURAN-2-ONE DERIVATIVES WITH ANTIBIOTIC ACTIVITY | AstraZeneca AB (SE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997014690-A1 | 5-(ACETAMIDOMETHYL)-3-ARYLDIHYDROFURAN-2-ONE AND TETRAHYDROFURAN-2-ONE DERIVATIVES WITH ANTIBIOTIC ACTIVITY | ZENECA LIMITED (GB) | 1997-04-24 | — | — | WO | disclosed |