SCHEMBL8655484

SCHEMBL8655484

COC(=O)Cc1cccc(CC(=O)Cl)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 0.59
ALDH1A1 P00352 3/20 0.50
GAA P10253 1/20 0.50
GFER P55789 1/20 0.50
HSP90AB1 P08238 1/20 0.50
CYP4F2 P78329 1/20 0.47
CYP4A11 Q02928 1/20 0.47
HPGD P15428 3/20 0.47
TSHR P16473 2/20 0.47
MAPT P10636 1/20 0.47
KDM4E B2RXH2 1/20 0.45
LMNA P02545 1/20 0.45
SMN1; SMN2 Q16637 3/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
PDK2 Q15119 1/20 0.43
PKM P14618 1/20 0.43
NFKB1 P19838 1/20 0.43
NFKB2 Q00653 1/20 0.43
RELA Q04206 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12400239 0.91 SLC7A5 (0.68) SLC7A5ALDH1A1GAAGFERHSP90AB1
SCHEMBL480042 0.86 SLC7A5 (0.59) SLC7A5ALDH1A1GAAGFERHSP90AB1
SCHEMBL4394735 0.85 SLC7A5 (0.62) SLC7A5ALDH1A1GAAGFERHSP90AB1
SCHEMBL9650739 0.85 CYP4F2 (0.63) ALDH1A1GAAGFERHSP90AB1CYP4F2
SCHEMBL4191880 0.84 CTBP2 (0.44) ALDH1A1
SCHEMBL12508635 0.84 SLC7A5 (0.60) SLC7A5ALDH1A1GAAGFERHSP90AB1
SCHEMBL694460 0.84 SLC7A5 (0.65) SLC7A5ALDH1A1GAAGFERHSP90AB1
SCHEMBL1560308 0.84 SLC7A5 (0.65) SLC7A5ALDH1A1GAAGFERHSP90AB1
SCHEMBL7718934 0.84 SLC7A5 (0.60) SLC7A5ALDH1A1GAAGFERHSP90AB1
SCHEMBL968785 0.83 SLC7A5 (0.52) SLC7A5ALDH1A1GAAGFERHSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0714893-B1 2-substituted benzothiazole derivatives useful in the treatment of diabetic complications GRELAN PHARMACEUTICAL CO (JP) 1998-10-21 EP disclosed
US-5700819-A ALDOSE REDUCTASE ENZYME INHIBITOR GRELAN PHARMACEUTICAL CO., LTD. (JP) 1997-12-23 US disclosed
EP-0714893-A1 2-substituted benzothiazole derivatives useful in the treatment of diabetic complications GRELAN PHARMACEUTICAL CO., LTD. (JP) 1996-06-05 EP disclosed