SCHEMBL4191880

SCHEMBL4191880

O=C(Cl)Cc1cccc(CC(=O)Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CTBP2 P56545 3/20 0.44
CES2 O00748 1/20 0.42
CES1 P23141 1/20 0.42
AKR1B1 P15121 1/20 0.42
HTR3E A5X5Y0 1/20 0.41
HTR3B O95264 1/20 0.41
HTR3A P46098 1/20 0.41
HTR3D Q70Z44 1/20 0.41
HTR3C Q8WXA8 1/20 0.41
PIK3CA P42336 1/20 0.41
ALDH1A1 P00352 2/20 0.40
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
EPHX2 P34913 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8255903 0.89 BCL2 (0.46) CTBP2ALDH1A1MEN1KMT2A
SCHEMBL27550263 0.89 PNMT (0.50) ALDH1A1
SCHEMBL23276465 0.87 CTBP2 (0.56) CTBP2ALDH1A1KMT2A
SCHEMBL1350536 0.87 CTBP2 (0.61) CTBP2HTR3EHTR3BHTR3AHTR3D
SCHEMBL10488625 0.86 NLRP3 (0.41)
SCHEMBL10386674 0.85 CYP1A2 (0.46) CTBP2
SCHEMBL30544187 0.85 CTBP2 (0.57) CTBP2ALDH1A1
SCHEMBL18412078 0.85 ALDH1A1 (0.46) CTBP2ALDH1A1MEN1KMT2A
SCHEMBL726784 0.85 CTBP2 (0.57) CTBP2ALDH1A1
SCHEMBL1149255 0.85 TAAR1 (0.47) CES2CES1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116003793-A Polyamide-imide film and preparation method thereof 株洲时代华昇新材料技术有限公司 2023-04-25 CN disclosed
US-11622958-B2 Bifunctional prodrugs Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts (DE) 2023-04-11 US disclosed
US-20190210992-A1 AGONISTS THAT ENHANCE BINDING OF INTEGRIN-EXPRESSING CELLS TO INTEGRIN RECEPTORS TEXAS HEART INSTITUTE (US) 2019-07-11 US disclosed
US-10287264-B2 Agonists that enhance binding of integrin-expressing cells to integrin receptors TEXAS HEART INSTITUTE (US) 2019-05-14 US disclosed
US-20180311212-A1 BIFUNCTIONAL PRODRUGS GEORG-AUGUST-UNIVERSITAET GOETTINGEN STIFTUNG OEFFENTLICHEN RECHS (DE) 2018-11-01 US disclosed
EP-3388429-A1 AGONISTS THAT ENHANCE BINDING OF INTEGRIN-EXPRESSING CELLS TO INTEGRIN RECEPTORS Texas Heart Institute (US) 2018-10-17 EP disclosed
US-10071980-B2 Agonists that enhanced binding of integrin-expressing cells to integrin receptors TEXAS HEART INSTITUTE (US) 2018-09-11 US disclosed
EP-3368091-A1 BIFUNCTIONAL PRODRUGS Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts (DE) 2018-09-05 EP disclosed
US-10035784-B2 Agonists that enhanced binding of integrin-expressing cells to integrin receptors TEXAS HEART INSTITUTE (US) 2018-07-31 US disclosed
EP-2881392-B1 Agonists that enhance binding of integrin-expressing cells to integrin receptors TEXAS HEART INST (US) 2018-06-06 EP disclosed
US-7863334-B2 Guanylhydrazone compounds, compositions, methods of making and using CYTOKINE PHARMASCIENCES, INC. (US) 2011-01-04 US disclosed
US-7635741-B2 Curable polyacetylenes used as dielectrics in making microelectronics such as integrated circuits DOW GLOBAL TECHNOLOGIES INC. 2009-12-22 US disclosed
US-20080070959-A1 GUANYLHYDRAZONE COMPOUNDS, COMPOSITIONS, METHODS OF MAKING AND USING CYTOKINE PHARMASCIENCES, INC. (US) 2008-03-20 US disclosed
US-20080070959-A1 GUANYLHYDRAZONE COMPOUNDS, COMPOSITIONS, METHODS OF MAKING AND USING CYTOKINE PHARMASCIENCES, INC. (US) 2008-03-20 US disclosed
US-7291647-B2 Guanylhydrazone compounds, compositions, methods of making and using CYTOKINE PHARMASCIENCES, INC. (US) 2007-11-06 US disclosed
US-7291647-B2 Guanylhydrazone compounds, compositions, methods of making and using CYTOKINE PHARMASCIENCES, INC. (US) 2007-11-06 US disclosed
EP-1476416-A2 MULTIFUNCTIONAL MONOMERS AND THEIR USE IN MAKING CROSS-LINKED POLYMERS AND POROUS FILMS DOW GLOBAL TECHNOLOGIES INC. (US) 2004-11-17 EP disclosed
US-20040053033-A1 Multifunctional monomers and their use in making cross-linked polymers and porous films NIU Q JASON (US) 2004-03-18 US disclosed
WO-2003068825-A2 MULTIFUNCTIONAL MONOMERS AND THEIR USE IN MAKING CROSS-LINKED POLYMERS AND POROUS FILMS DOW GLOBAL TECHNOLOGIES INC. (US) 2003-08-21 WO disclosed
US-5670493-A ANGIOGENESIS INHIBITORS ADIR ET COMPAGNIE (FR) 1997-09-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10035784-B2 Agonists that enhanced binding of integrin-expressing cells to integrin receptors ITGB7, ITGAL, ITGB1 CTBP2 1820/4885CES2 2890/4885CES1 2397/4885
US-20180311212-A1 BIFUNCTIONAL PRODRUGS PAICS, FCGRT, ENTPD1 CTBP2 2494/4885CES2 451/4885CES1 142/4885
US-20190210992-A1 AGONISTS THAT ENHANCE BINDING OF INTEGRIN-EXPRESSING CELLS TO INTEGRIN RECEPTORS ITGB7, ITGAL, ITGB1 CTBP2 1931/4885CES2 2912/4885CES1 2406/4885
US-20080070959-A1 GUANYLHYDRAZONE COMPOUNDS, COMPOSITIONS, METHODS OF MAKING AND USING GMPS, GANC, GLO1 CTBP2 3412/4885CES2 245/4885CES1 1631/4885
US-10287264-B2 Agonists that enhance binding of integrin-expressing cells to integrin receptors ITGB7, ITGAL, ITGB1 CTBP2 1808/4885CES2 2782/4885CES1 2370/4885
US-11622958-B2 Bifunctional prodrugs PAICS, FCGRT, ENTPD1 CTBP2 2494/4885CES2 451/4885CES1 142/4885
US-10071980-B2 Agonists that enhanced binding of integrin-expressing cells to integrin receptors ITGB7, ITGAL, ITGB1 CTBP2 1820/4885CES2 2890/4885CES1 2397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.