Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 6/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8672436 | 0.89 | HDAC8 (0.34) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL8654114 | 0.88 | HDAC8 (0.40) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL8654109 | 0.88 | EPHX1 (0.41) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL9745321 | 0.78 | HDAC8 (0.40) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL8653355 | 0.75 | ALDH1A1 (0.37) | ALDH1A1KDM4EKMT2AL3MBTL1 | |
| SCHEMBL8616623 | 0.75 | HDAC8 (0.42) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL15271899 | 0.74 | KDM4E (0.65) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL10940544 | 0.74 | KDM4E (0.65) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL28425391 | 0.74 | KDM4E (0.65) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL15269112 | 0.74 | KDM4E (0.65) | HDAC8HDAC3HDAC6HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579769-B1 | 2- AND 5-ALKYL AND PHENYL SUBSTITUTED 4-(1-HYDROXY, 1-ACYLOXY OR 1-CARBAMOYLOXY)-5-HYDROXY-2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | ALLERGAN INC (US) | 1998-10-21 | — | — | EP | claimed |
| EP-0579769-A1 | 2- AND 5-ALKYL AND PHENYL SUBSTITUTED 4-(1-HYDROXY, 1-ACYLOXY OR 1-CARBAMOYLOXY)-5-HYDROXY-2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1994-01-26 | — | — | EP | claimed |
| US-5183906-A | Antibody inhibitors, antiarthritic agents, antiallergens | ALLERGAN, INC. (US) | 1993-02-02 | — | — | US | claimed |
| WO-1992019610-A1 | 2- AND 5-ALKYL AND PHENYL SUBSTITUTED 4-(1-HYDROXY, 1-ACYLOXY OR 1-CARBAMOYLOXY)-5-HYDROXY-2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1992-11-12 | — | — | WO | claimed |
| EP-0579769-B1 | 2- AND 5-ALKYL AND PHENYL SUBSTITUTED 4-(1-HYDROXY, 1-ACYLOXY OR 1-CARBAMOYLOXY)-5-HYDROXY-2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | ALLERGAN INC (US) | 1998-10-21 | — | — | EP | disclosed |
| US-5541221-A | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss | ALLERGAN (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0637240-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 3 AND 4-SUBSTITUTED 2(5H)-FURANONES FOR INHIBITING BONE LOSS | ALLERGAN, INC. (US) | 1995-02-08 | — | — | EP | disclosed |
| US-5387606-A | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss | ALLERGAN, INC. (US) | 1995-02-07 | — | — | US | disclosed |
| US-5322953-A | Antiinflammatory agents; intermediates for 2-furanone compounds | ALLERGAN, INC. (US) | 1994-06-21 | — | — | US | disclosed |
| US-5298633-A | Silane intermediates | ALLERGAN, INC. (US) | 1994-03-29 | — | — | US | disclosed |
| EP-0579769-A1 | 2- AND 5-ALKYL AND PHENYL SUBSTITUTED 4-(1-HYDROXY, 1-ACYLOXY OR 1-CARBAMOYLOXY)-5-HYDROXY-2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1994-01-26 | — | — | EP | disclosed |
| US-5268387-A | Containing ester or carbamate group | ALLERGAN, INC. (US) | 1993-12-07 | — | — | US | disclosed |
| WO-1993021915-A1 | PHARMACEUTICAL COMPOSITIONS FOR INHIBITING BONE LOSS CONTAINING 3 AND 4-SUBSTITUTED 2(5H)-FURANONES | ALLERGAN, INC. (US) | 1993-11-11 | — | — | WO | disclosed |
| US-5183906-A | Antibody inhibitors, antiarthritic agents, antiallergens | ALLERGAN, INC. (US) | 1993-02-02 | — | — | US | disclosed |
| US-5171863-A | 2-trialkylsily-4-substituted furan derivatives | ALLERGAN, INC. (US) | 1992-12-15 | — | — | US | disclosed |
| WO-1992019610-A1 | 2- AND 5-ALKYL AND PHENYL SUBSTITUTED 4-(1-HYDROXY, 1-ACYLOXY OR 1-CARBAMOYLOXY)-5-HYDROXY-2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1992-11-12 | — | — | WO | disclosed |
| US-5082954-A | Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-01-21 | — | — | US | disclosed |