Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.45 |
| ▸ | HTR2C | P28335 | 5/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.44 |
| ▸ | PRKCB | P05771 | 4/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.40 |
| ▸ | PRKCG | P05129 | 2/20 | 0.40 |
| ▸ | PRKCA | P17252 | 2/20 | 0.40 |
| ▸ | PRKCH | P24723 | 2/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.40 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | PHKA2 | P46019 | 1/20 | 0.40 |
| ▸ | PHKA1 | P46020 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | PHKG1 | Q16816 | 1/20 | 0.40 |
| ▸ | PHKB | Q93100 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8655904 | 0.81 | PRKCE (0.51) | HTR2AHTR2CSIGMAR1PRKCBPRKCE | |
| SCHEMBL1991214 | 0.81 | HTR2A (0.48) | HTR2AHTR2CSIGMAR1PRKCBPRKCE | |
| SCHEMBL8318760 | 0.81 | HTR2A (0.48) | HTR2AHTR2CSIGMAR1PRKCBPRKCE | |
| SCHEMBL8324461 | 0.81 | HTR2A (0.48) | HTR2AHTR2CSIGMAR1PRKCBPRKCE | |
| SCHEMBL8451898 | 0.78 | HTR2A (0.42) | HTR2AHTR2CSIGMAR1PRKCEMYLK | |
| SCHEMBL8451901 | 0.78 | HTR2A (0.42) | HTR2AHTR2CSIGMAR1PRKCEMYLK | |
| SCHEMBL8449854 | 0.77 | SIGMAR1 (0.49) | HTR2AHTR2CSIGMAR1PRKCEMYLK | |
| SCHEMBL8448934 | 0.76 | HTR2A (0.40) | HTR2AHTR2CSIGMAR1PRKCEMYLK | |
| SCHEMBL6015848 | 0.76 | SIGMAR1 (0.44) | HTR2AHTR2CSIGMAR1PRKCEMYLK | |
| SCHEMBL1999141 | 0.76 | HTR2A (0.40) | HTR2AHTR2CSIGMAR1PRKCEMYLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079105-A1 | NOVEL THIENOPYRROLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079105-A1 | NOVEL THIENOPYRROLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-30 | — | — | WO | disclosed |
| US-20110152243-A1 | NOVEL THIENOPYRROLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110152243-A1 | NOVEL THIENOPYRROLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110152243-A1 | NOVEL THIENOPYRROLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152243-A1 | NOVEL THIENOPYRROLE COMPOUNDS | TPMT, TSLP, THPO | HTR2A 1080/4885HTR2C 648/4885SIGMAR1 512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.