Known targets — ChEMBL curated mechanism
POLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PRIM1PRIM2
The experimentally established mechanism targets of E626. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.67 |
| ▸ | TGM2 | P21980 | 1/20 | 0.62 |
| ▸ | IMPDH2 | P12268 | 7/20 | 0.62 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.62 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.59 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.59 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.59 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.59 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.59 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.58 |
| ▸ | KRAS | P01116 | 2/20 | 0.57 |
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.57 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.57 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cytarabine 5'-Phosphate SCHEMBL249411 | 1.00 | NT5E (0.67) | NT5ETGM2IMPDH2IMPDH1P2RY2 | |
| Cytarabine 5'-Phosphate SCHEMBL28224063 | 1.00 | NT5E (0.67) | NT5ETGM2IMPDH2IMPDH1P2RY2 | |
| E626 SCHEMBL16245477 | 0.97 | NT5E (0.71) | NT5ETGM2IMPDH2IMPDH1P2RY2 | |
| E626 SCHEMBL6534995 | 0.94 | NT5E (0.60) | NT5ETGM2IMPDH2IMPDH1P2RY2 | |
| Guanosine SCHEMBL1983917 | 0.93 | LMNA (0.64) | NT5ETGM2P2RY2P2RY4P2RY6 | |
| SCHEMBL18281060 | 0.92 | NT5E (0.71) | NT5ETGM2IMPDH2IMPDH1P2RY2 | |
| SCHEMBL1983921 | 0.92 | NT5E (0.71) | NT5ETGM2IMPDH2IMPDH1P2RY2 | |
| E626 SCHEMBL2775605 | 0.92 | NT5E (0.77) | NT5ETGM2IMPDH2IMPDH1TAS1R3 | |
| SCHEMBL8611555 | 0.92 | TGM2 (0.62) | NT5ETGM2IMPDH2IMPDH1P2RY2 | |
| SCHEMBL8616145 | 0.92 | TGM2 (0.62) | NT5ETGM2IMPDH2IMPDH1P2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712256-A | WOUND HEALING, YEASTS, ADENIN OR ADENOSINE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 1998-01-27 | — | — | US | disclosed |