Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4146675 | 0.81 | MAPT (0.33) | EPHX1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL992491 | 0.80 | GAA (0.32) | EPHX1MAPT | |
| SCHEMBL5412235 | 0.66 | GAA (0.37) | KDM4ELMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8197993 | 0.66 | MAPT (0.37) | KDM4ELMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4915107 | 0.66 | GAA (0.37) | KDM4EMEN1KMT2AMAPTRAB9A | |
| SCHEMBL8799466 | 0.65 | GAA (0.43) | MAPT | |
| SCHEMBL1226277 | 0.64 | MAPT (0.42) | LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL5414764 | 0.63 | MAPT (0.41) | KDM4EMEN1LMNAKMT2AMAPT | |
| SCHEMBL15865155 | 0.63 | MAPT (0.37) | LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL28986970 | 0.63 | ALDH1A1 (0.36) | MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730453-A4 | METHODS OF TREATING CARDIAC ARRHYTHMIA | MERCK & CO INC (US) | 1998-03-04 | — | — | EP | disclosed |
| EP-0730453-A1 | METHODS OF TREATING CARDIAC ARRHYTHMIA | MERCK & CO. INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014470-A1 | METHODS OF TREATING CARDIAC ARRHYTHMIA | MERCK & CO., INC. (US) | 1995-06-01 | — | — | WO | disclosed |