Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.49 |
| ▸ | RAF1 | P04049 | 6/20 | 0.47 |
| ▸ | KDR | P35968 | 6/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.46 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.46 |
| ▸ | LYN | P07948 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.46 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | FRK | P42685 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8657705 | 0.90 | TLR8 (0.60) | TLR8TLR7RAF1KDRMAPK14 | |
| SCHEMBL8656260 | 0.86 | GCGR (0.47) | KDRMAPK14TNNI3KBRAFEGFR | |
| SCHEMBL8662540 | 0.85 | TDP1 (0.59) | TLR8TLR7RAF1KDRMAPK14 | |
| SCHEMBL8658884 | 0.81 | TLR8 (0.58) | TLR8TLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL9720327 | 0.78 | GCGR (0.51) | TLR8TLR7KDRMAPK14TNNI3K | |
| SCHEMBL8658849 | 0.78 | TLR8 (0.56) | TLR8TLR7RAF1KDRMAPK14 | |
| SCHEMBL8621586 | 0.77 | IL2 (0.54) | TLR8TLR7KDRBRAFMAPK1 | |
| SCHEMBL8657704 | 0.77 | TLR8 (0.48) | TLR8TLR7KDRMAPK14TNNI3K | |
| SCHEMBL8662619 | 0.76 | TLR8 (0.59) | TLR8TLR7RAF1KDRMAPK14 | |
| SCHEMBL8657144 | 0.75 | TLR8 (0.59) | TLR8TLR7MAPK1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776981-A | Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals | NOVARTIS CORPORATION (US) | 1998-07-07 | — | — | US | disclosed |
| US-5776982-A | Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals | NOVARTIS CORPORATION (US) | 1998-07-07 | — | — | US | disclosed |