Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 12/20 | 0.60 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.60 |
| ▸ | IL2 | P60568 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8658884 | 0.91 | TLR8 (0.58) | TLR8TLR7IL2ALDH1A1 | |
| SCHEMBL8656261 | 0.90 | TLR8 (0.49) | TLR8TLR7KDM4ENPC1ALDH1A1 | |
| SCHEMBL8621586 | 0.88 | IL2 (0.54) | TLR8TLR7IL2KDM4ENPC1 | |
| SCHEMBL8662619 | 0.86 | TLR8 (0.59) | TLR8TLR7IL2KDM4ENPC1 | |
| SCHEMBL8657704 | 0.86 | TLR8 (0.48) | TLR8TLR7IL2KDM4ENPC1 | |
| SCHEMBL8662540 | 0.86 | TDP1 (0.59) | TLR8TLR7NPC1ALDH1A1MAPK1 | |
| SCHEMBL8657144 | 0.85 | TLR8 (0.59) | TLR8TLR7IL2KDM4ENPC1 | |
| SCHEMBL9324671 | 0.84 | TLR8 (0.57) | TLR8TLR7IL2KDM4ENPC1 | |
| SCHEMBL9743573 | 0.82 | MEN1 (0.54) | TLR8TLR7IL2ALDH1A1KDR | |
| SCHEMBL8662609 | 0.79 | TLR8 (0.54) | TLR8TLR7IL2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776981-A | Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals | NOVARTIS CORPORATION (US) | 1998-07-07 | — | — | US | disclosed |
| US-5776982-A | Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals | NOVARTIS CORPORATION (US) | 1998-07-07 | — | — | US | disclosed |