Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 3/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763733 | 0.76 | TSHR (0.41) | TSHRMMP8ALDH1A1PRKCASMN1; SMN2 | |
| SCHEMBL18924771 | 0.74 | TSHR (0.39) | TSHRMMP8ALDH1A1PRKCASMN1; SMN2 | |
| SCHEMBL12761590 | 0.74 | TSHR (0.39) | TSHRMMP8ALDH1A1PRKCASMN1; SMN2 | |
| SCHEMBL23065063 | 0.73 | SMN1; SMN2 (0.40) | TSHRMMP8ALDH1A1PRKCASMN1; SMN2 | |
| SCHEMBL4678856 | 0.71 | TSHR (0.43) | TSHRMMP8ALDH1A1PRKCASMN1; SMN2 | |
| SCHEMBL7945587 | 0.71 | TSHR (0.46) | TSHRMMP8ALDH1A1PRKCASMN1; SMN2 | |
| SCHEMBL685935 | 0.71 | PRKCA (0.55) | TSHRMMP8ALDH1A1PRKCASMN1; SMN2 | |
| SCHEMBL1785988 | 0.71 | TSHR (0.46) | TSHRMMP8ALDH1A1PRKCASMN1; SMN2 | |
| SCHEMBL12310627 | 0.70 | SMN1; SMN2 (0.45) | TSHRMMP8ALDH1A1PRKCACA2 | |
| SCHEMBL12305438 | 0.70 | MMP8 (0.37) | TSHRMMP8ALDH1A1PRKCACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756498-A | Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |