Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.63 |
| ▸ | SNCA | P37840 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TDO2 | P48775 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.51 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540445 | 0.84 | GPR84 (0.63) | GPR84SNCAIDO1HTR2ATRPM8 | |
| SCHEMBL5725721 | 0.84 | GPR84 (0.63) | GPR84TDO2HTR2ATRPM8KMT2A | |
| SCHEMBL8658685 | 0.84 | GAA (0.56) | SNCAIDO1PCSK9HTR2AKMT2A | |
| SCHEMBL5870915 | 0.81 | MEN1 (0.68) | GPR84PKMKMT2AAHR | |
| SCHEMBL8658847 | 0.81 | GPR84 (0.66) | GPR84HTR2ATRPM8AHR | |
| SCHEMBL8656583 | 0.81 | SLC6A4 (0.48) | SNCA | |
| Hydrochloric Acid SCHEMBL8658852 | 0.80 | GPR84 (0.64) | GPR84HTR2ATRPM8AHR | |
| SCHEMBL18383117 | 0.79 | GPR84 (1.00) | GPR84IDO1TBXAS1PCSK9HTR2A | |
| SCHEMBL8541224 | 0.79 | CYP19A1 (0.53) | SNCAPKMKMT2A | |
| SCHEMBL9938871 | 0.78 | SNCA (1.00) | SNCAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834493-A | TREATMENT OF NERVOUS SYSTEM DISORDERS | GIL QUINTERO MYRNA (IT) | 1998-11-10 | — | — | US | disclosed |
| CN-1124960-A | Indole derivatives as 5-HT1A and/or 5-HT2 ligands | BOEHRINGER INGELHEIM ITALIA (IT) | 1996-06-19 | — | — | CN | disclosed |
| EP-0694033-A1 | INDOLE DERIVATIVES AS 5-HT1A AND/OR 5-HT2 LIGANDS | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1996-01-31 | — | — | EP | disclosed |
| WO-1994024125-A1 | INDOLE DERIVATIVES AS 5-HT1A AND/OR 5-HT2 LIGANDS | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1994-10-27 | — | — | WO | disclosed |