Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 4/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SPR | P35270 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540445 | 0.84 | GPR84 (0.63) | HTR1DHTR2ASNCAIDO1GABRA1 | |
| SCHEMBL5725721 | 0.84 | GPR84 (0.63) | HTR2AKMT2AHTR1ASLC6A4 | |
| SCHEMBL8657374 | 0.84 | GPR84 (0.63) | PCSK9HTR2ASNCAIDO1KMT2A | |
| SCHEMBL8658847 | 0.83 | GPR84 (0.66) | HTR1DHTR2AHTR1BMTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL8658852 | 0.82 | GPR84 (0.64) | HTR1DHTR2AHTR1BMTNR1AMTNR1B | |
| SCHEMBL5870915 | 0.81 | MEN1 (0.68) | MEN1KMT2AMETHTR6 | |
| SCHEMBL8656583 | 0.81 | SLC6A4 (0.48) | SNCAHTR1ADRD2SLC6A4DRD3 | |
| SCHEMBL14194176 | 0.80 | CYP3A4 (0.60) | MET | |
| SCHEMBL18383116 | 0.79 | HTR1D (0.69) | PCSK9HTR1DHTR2AHTR1BMEN1 | |
| SCHEMBL8541224 | 0.79 | CYP19A1 (0.53) | GAASNCAGABRA1GABRB2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834493-A | TREATMENT OF NERVOUS SYSTEM DISORDERS | GIL QUINTERO MYRNA (IT) | 1998-11-10 | — | — | US | disclosed |
| CN-1124960-A | Indole derivatives as 5-HT1A and/or 5-HT2 ligands | BOEHRINGER INGELHEIM ITALIA (IT) | 1996-06-19 | — | — | CN | disclosed |
| EP-0694033-A1 | INDOLE DERIVATIVES AS 5-HT1A AND/OR 5-HT2 LIGANDS | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1996-01-31 | — | — | EP | disclosed |
| WO-1994024125-A1 | INDOLE DERIVATIVES AS 5-HT1A AND/OR 5-HT2 LIGANDS | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1994-10-27 | — | — | WO | disclosed |