Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | SPR | P35270 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22151988 | 0.89 | CHRNB2 (0.50) | GPR84MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL8657374 | 0.84 | GPR84 (0.63) | GPR84KMT2APKMHTR2ATRPM8 | |
| SCHEMBL8658685 | 0.84 | GAA (0.56) | MEN1KMT2AHTR2ASNCASLC6A4 | |
| SCHEMBL5725721 | 0.84 | GPR84 (0.63) | GPR84KMT2AHTR2ATRPM8SLC6A4 | |
| SCHEMBL28547448 | 0.83 | GPR84 (0.75) | GPR84MEN1KMT2ACYP3A4HTR2A | |
| SCHEMBL31744847 | 0.81 | GPR84 (0.73) | GPR84MEN1KMT2ACYP3A4HTR2A | |
| SCHEMBL5870915 | 0.81 | MEN1 (0.68) | GPR84MEN1KMT2ACYP3A4PKM | |
| SCHEMBL8658847 | 0.81 | GPR84 (0.66) | GPR84CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8656583 | 0.81 | SLC6A4 (0.48) | SNCASLC6A4HTR1A | |
| Hydrochloric Acid SCHEMBL8658852 | 0.80 | GPR84 (0.64) | GPR84CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834493-A | TREATMENT OF NERVOUS SYSTEM DISORDERS | GIL QUINTERO MYRNA (IT) | 1998-11-10 | — | — | US | disclosed |
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | disclosed |
| CN-1124960-A | Indole derivatives as 5-HT1A and/or 5-HT2 ligands | BOEHRINGER INGELHEIM ITALIA (IT) | 1996-06-19 | — | — | CN | disclosed |
| EP-0694033-A1 | INDOLE DERIVATIVES AS 5-HT1A AND/OR 5-HT2 LIGANDS | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1996-01-31 | — | — | EP | disclosed |
| WO-1995006046-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LIMITED (GB) | 1995-03-02 | — | — | WO | disclosed |
| WO-1994024125-A1 | INDOLE DERIVATIVES AS 5-HT1A AND/OR 5-HT2 LIGANDS | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1994-10-27 | — | — | WO | disclosed |