SCHEMBL8658147

SCHEMBL8658147

COC(=O)c1ccc(C(=O)Nc2ccccc2NC(=O)c2ccc(C(=O)OC)cc2)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F10 P00742 1/20 0.71
TSHR P16473 2/20 0.64
CYP1A2 P05177 1/20 0.64
CYP2D6 P10635 1/20 0.64
CYP2C19 P33261 1/20 0.64
PTPN1 P18031 1/20 0.63
KMT2A Q03164 4/20 0.62
MEN1 O00255 3/20 0.62
MAPT P10636 3/20 0.59
GAA P10253 1/20 0.59
MAPK1 P28482 1/20 0.59
APOBEC3A P31941 1/20 0.58
APOBEC3G Q9HC16 1/20 0.58
RAB9A P51151 4/20 0.57
NPC1 O15118 3/20 0.57
ATM Q13315 1/20 0.57
HDAC3 O15379 1/20 0.57
HDAC4 P56524 1/20 0.57
HDAC1 Q13547 1/20 0.57
HDAC7 Q8WUI4 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1366907 0.89 PTPN1 (0.60) F10TSHRCYP1A2CYP2D6CYP2C19
SCHEMBL2411022 0.88 HDAC1 (0.75) F10MAPTGAAMAPK1RAB9A
SCHEMBL9620767 0.88 MLYCD (0.69) F10TSHRCYP1A2CYP2D6CYP2C19
SCHEMBL30944732 0.86 F10 (0.55) F10TSHRCYP1A2CYP2D6CYP2C19
SCHEMBL1062994 0.86 F10 (0.55) F10TSHRCYP1A2CYP2D6CYP2C19
SCHEMBL6439783 0.84 F10 (0.73) F10PTPN1KMT2AMEN1MAPT
SCHEMBL2835923 0.83 PTPN1 (0.81) TSHRPTPN1KMT2AMEN1MAPT
SCHEMBL2414416 0.83 PHGDH (0.70) KMT2AMEN1MAPTGAAMAPK1
SCHEMBL62930 0.81 PTPN1 (0.90) TSHRPTPN1KMT2AMEN1MAPT
SCHEMBL976440 0.81 NPC1 (0.51) F10TSHRCYP1A2CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0724568-B1 AMIDO PEROXYCARBOXYLIC ACIDS FOR BLEACHING UNILEVER PLC (GB) 1998-11-04 EP disclosed
EP-0564251-B1 Amido peroxycarboxylic acids UNILEVER PLC (GB) 1995-09-06 EP disclosed
US-5397501-A Composition with surfactants for bleaching fabrics LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) 1995-03-14 US disclosed
US-5268003-A Or salt thereof LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) 1993-12-07 US disclosed
EP-0564251-A2 Amido peroxycarboxylic acids UNILEVER PLC (GB) 1993-10-06 EP disclosed
EP-0564250-A2 Structured liquid detergent compositions containing amido and imido peroxy acids UNILEVER PLC (GB) 1993-10-06 EP disclosed