SCHEMBL9620767

SCHEMBL9620767

COC(=O)c1ccc(C(=O)Nc2ccccc2OC)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 1/20 0.69
PABPC1 P11940 1/20 0.67
APOBEC3A P31941 1/20 0.67
EIF4H Q15056 1/20 0.67
APOBEC3G Q9HC16 1/20 0.67
KMT2A Q03164 3/20 0.65
AHR P35869 2/20 0.65
MEN1 O00255 1/20 0.65
HPGD P15428 2/20 0.63
NPC1 O15118 4/20 0.61
RAB9A P51151 4/20 0.61
F10 P00742 1/20 0.61
MAPT P10636 2/20 0.61
POLB P06746 1/20 0.61
NPSR1 Q6W5P4 1/20 0.61
P4HTM Q9NXG6 1/20 0.60
TSHR P16473 2/20 0.60
CYP1A2 P05177 1/20 0.60
CYP2D6 P10635 1/20 0.60
CYP2C19 P33261 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29989592 0.88 RAB9A (0.77) MLYCDPABPC1APOBEC3AEIF4HAPOBEC3G
SCHEMBL527994 0.88 RAB9A (0.77) MLYCDPABPC1APOBEC3AEIF4HAPOBEC3G
SCHEMBL8658147 0.88 F10 (0.71) APOBEC3AAPOBEC3GKMT2AAHRMEN1
SCHEMBL9620772 0.87 F10 (0.81) MLYCDPABPC1APOBEC3AEIF4HAPOBEC3G
SCHEMBL16583906 0.87 RAB9A (0.70) MLYCDPABPC1APOBEC3AEIF4HAPOBEC3G
SCHEMBL8970971 0.87 POLB (0.70) MLYCDPABPC1APOBEC3AEIF4HAPOBEC3G
SCHEMBL682871 0.86 GAA (0.68) MLYCDPABPC1APOBEC3AEIF4HAPOBEC3G
SCHEMBL96146 0.86 MLYCD (0.68) MLYCDPABPC1APOBEC3AEIF4HAPOBEC3G
SCHEMBL16681360 0.85 KMT2A (0.76) MLYCDPABPC1APOBEC3AEIF4HAPOBEC3G
SCHEMBL9620749 0.84 HPGD (0.74) KMT2AMEN1HPGDRAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0306708-B1 NOVEL BENZOTHIAZOLE AND ANTIRHEUMATIC AGENT COMPRISING IT AS AN ACTIVE INGREDIENT KANEBO, LTD. (JP) 1992-01-08 EP disclosed
US-4910211-A Containing a phenyl substituted in position 2 and an ester in position 4 KANEBO LTD. (JP) 1990-03-20 US disclosed
EP-0306708-A1 Novel benzothiazole and antirheumatic agent comprising it as an active ingredient KANEBO, LTD. (JP) 1989-03-15 EP disclosed